19 October-1 December 2020
The 51st Union World Conference On Lung Health
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Channel 1
Opening Ceremony
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Opening Ceremony
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Opening Ceremony: Marking The Union's Centennial Year
20 October 2020              2PM-3PM CEST
 
On 20 October 1920, representatives from 31 countries, recognising that a global health crisis – tuberculosis – could not be defeated without international collaboration and knowledge sharing, came together and founded The Union. One hundred years later, as the world struggles to confront a new infectious respiratory disease – COVID-19 – our founders’ vision remains as relevant as ever.

As The Union turns a century old, we also embark upon the first ever virtual Union World Conference. The opening ceremony will reflect on the journey so far and the distance left to travel.
 
We will hear from:
 - Her Imperial Highness Crown Princess Akishino of Japan
- President Bill Clinton
- World Health Organization Director-General Dr Tedros Adhanom Ghebreyesus
- Yvonne Chaka Chaka, singer, entrepreneur, Global Health Advocate and humanitarian
- Divya Sojan, TB survivor and nurse
- Shannon Hader, Deputy Executive Director United Nations Programme on HIV/AIDS (UNAIDS)
- Katherine Maher, Chief Executive of the Wikimedia Foundation (Interviewed by Noam Cohen, WIRED)
- Claire Forlani, UK Film and TV Actress, and The Union’s TB Ambassador
- Dr Tamaryn Green, TB Survivor, Medical Doctor, Miss South Africa 2018
 
President of The Union, Professor Guy Marks, The Union’s Executive Director, José Luis Castro, and Dr Keren Middelkoop, Chair Coordinating Committee of Scientific Activities will also speak.

Please join our opening ceremony and we wish you an inspiring virtual Union World Conference.

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Channel 3
MTE-01-Meet the expert session: civil society
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MTE-01-Meet the expert session: civil society
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Health advocacy for access to care

Alternative respond to Covid-19 by the Civil Society Organisations in South Africa

Please note that the number of participants is limited to 50 for this session.

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Channel 4
MTE-02-Meet the expert session: Adult and Child Lung Health
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MTE-02-Meet the expert session: Adult and Child Lung Health
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TB vaccine for children

Please note that the number of participants is limited for this session.

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E-posters
EP01-Resisting the resistance
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EP01-Resisting the resistance
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All E-posters are accessible via the "E-posters" section of the conference platform until 30 November.

EP01-100-21-Pharmacokinetics of anti-TB drugs in multidrug-resistant TB patients in IndiaA pharmacokinetic (PK) study of drugs used to treat multidrug-resistant (MDR) tuberculosis (TB) was undertaken in 350 adult MDR-TB patients treated according to the prevailing guidelines in India. Factors influencing drug PK and end of intensive phase status were also determined. Results of this study will be discussed.
Agibothu Kupparam Hemanth Kumar

EP01-101-21-Multidrug-resistant TB and its determinants of health service, community and social context in the state of São Paulo, BrazilThis study presents the social determinants of health in relation to the occurrence of multidrug-resistant tuberculosis, key information for disease control in regions with great social inequity. We emphasise the importance of socioeconomic, demographic and health system structure conditions for the spread of the disease.
Ricardo Arcêncio

EP01-102-21-Decentralised care for rifampicin-resistant TB in Western Cape, South Africa: a laboratory cohort studySouth Africa implemented a policy to decentralise rifampicin-resistant tuberculosis (RR-TB) care in 2011. We used laboratory data from the Western Cape province to assess patterns of RR-TB care and identify changes in hospitalisation rates, length of hospital stay and travel burden from 2012-2014. We compared Cape Town with more rural districts.
Helen Jenkins

EP01-103-21-Effectiveness, safety and feasibility of nine-month treatment regimen for rifampin-resistant TB in the PhilippinesThe short nine-month multidrug-resistant tuberculosis regimen had a high treatment success rate (74 percent) with a favourable safety profile in a prospective single-arm study conducted in the Philippines during 07/2015-12/2016. Nine-month treatment regimen operational research had a major impact on building national capacity and infrastructure for programmatic adoption of the new regimen in country.
Vivian Lofranco

EP01-104-21-Characterising multidrug-resistant tuberculosis transmission in rural KwaZulu-Natal: a prospective cohort studyThis study combined whole genome sequencing of 129 Mycobacterium tuberculosis (Mtb) isolates with demographic data from patients with multidrug-resistant TB in KwaZulu-Natal, South Africa. Transmission clusters based on genomic differences were identified. Relationships between demographic characteristics, Mtb lineage, rpoB mutation and transmission clustering were examined, aiming to elucidate drivers of Mtb transmission.
Cassandra Fairhead

EP01-105-21-Effectiveness and safety of use of bedaquiline and delamanid in combination for drug-resistant extrapulmonary TB in Mumbai, IndiaMédecins Sans Frontières has been providing treatment, including bedaquiline and/or delamanid, to patients with drug-resistant tuberculosis (TB) in Mumbai since 2015. Cases are referred with complex resistance profiles and extensive treatment history. This study aims to describe the effectiveness and safety of use of bedaquiline and delamanid for drug-resistant extrapulmonary TB.
Himani Mongia

EP01-106-21-Eliciting patient preferences for different attributes of a community-based model for management of multidrug-resistant TB in Uganda: a discrete choice experimentThe advent of all-oral regimens for the management of multidrug- resistant tuberculosis makes the implementation of home-based treatment a possibility for this group of patients. However, to be successful, options for home-based care should take into consideration patient preferences for different aspects of care.    
Stella Zawedde-Muyanja

EP01-107-21-Treatment of multidrug-resistant TB with modified shorter all-oral treatment regimen: Belarus operational research studyIn October 2018, Belarus started to use mSTR for multidrug-resistant tuberculosis under operational research conditions. By 1st May 2020, 415 patients were included in the study and, of them, 114 had final treatment outcomes with encouraging results (89% of treatment success).
Alena Skrahina

EP01-108-21-Patient’s perspective on drug-resistant TB medication: does it matter? Putting research into action to develop information, education and communication materialA qualitative study of drug-resistant tuberculosis (DR-TB) treatment from the perspective and experience of patient, family, healthcare worker and psychologist in six health facilities within three districts of Indonesia as a basis for developing DR-TB information, education and communication material based on the Health Belief Model and Transtheoretical Model.
Ferdiana Yunita

EP01-109-21-The role of clinical healthcare champions in driving drug-resistant TB policy implementation in South AfricaIn South Africa, champions have emerged as a driving force behind the implementation of decentralised management of drug-resistant tuberculosis (DR-TB). This study explored the typology of champions in the decentralisation of DR-TB management, strategies that champions used to implement policy and the contextual factors that enabled or hindered their agency.
Sacha Le Roux

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E-posters
EP02-Challenges for randomised controlled trials on TB treatment
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EP02-Challenges for randomised controlled trials on TB treatment
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All E-posters are accessible via the "E-posters" section of the conference platform until 30 November.

EP02-110-21-International multicentre controlled trial to evaluate 1200mg and 1800mg rifampicin daily in the reduction of treatment duration for pulmonary TB from six to four monthsThe current treatment for drug-sensitive pulmonary tuberculosis (TB) involves taking drugs daily for six months. RIFASHORT is an international multicentre controlled clinical trial which evaluates higher doses of rifampicin with the objective of reducing the treatment duration for drug-sensitive pulmonary TB from six months to four months.
Tulika Munshi

EP02-111-21-Documenting challenges faced and lessons learned from implementation of STREAM – the world’s largest recruited multidrug-resistant TB clinical trialMulticountry clinical trial implementation is complex – from different regulatory requirements and approval processes to variable research infrastructure and capacity across settings. Here, we document challenges faced and lessons learned from STREAM – the first large-scale, multicountry clinical trial for multidrug-resistant tuberculosis.
Meera Gurumurthy

EP02-112-21-A method for baseline adjudication of TB diagnosis in children in a therapeutic clinical trial: experience from SHINEDiagnosing non-severe pulmonary tuberculosis (TB) in children is challenging.  Results in children adjudicated as having TB (in the SHINE trial comparing four vs six months of standard therapy) will be essential. The approach to adjudicate TB or not TB can help overcome challenges in paediatric TB studies in the absence of gold standard diagnostic tests.
Genevieve H Wills

EP02-113-21-Sustainability of the ACT4 randomised trial to improve initiation of TB preventive treatmentThe ACT4 randomised trial found that a health systems' intervention in strengthening management of latent tuberculosis (TB) infection was effective at increasing TB preventive therapy initiation rates in households contacts. In this follow up study, the sustainability of the ACT4 intervention was evaluated over the nine months following the end of the trial.
Olivia Oxlade

EP02-114-21-Utility of colour vision testing in screening for ethambutol-associated ocular toxicity in children treated for TB in the SHINE trialEthambutol-associated ocular toxicity (EAOT) is reported in 0.05-0.7% of children treated for tuberculosis (TB). Using a child-friendly colour vision test as a screening tool, there was no evidence of clinically significant EAOT in children taking ethambutol.  Colour vision testing in children is feasible but may not be necessary for standard drug-sensitive TB treatment.
Eric Wobudeya

EP02-115-21-Adolescents in a TB clinical treatment trial: characteristics of an under represented populationAdolescents represent approximately 10% of the global tuberculosis (TB) burden yet they are historically under represented in clinical trials, potentially limiting their access to new treatments. We examined enrolment patterns for adolescents in a TB Trials Consortium and AIDS Clinical Trials Group Phase III and rifapentine-containing treatment shortening trial for pulmonary TB (NCT02410772).
Kimberley Hedges

EP02-116-21-Investigator reported barriers and facilitators to adolescent recruitment, enrolment and retention in TB Trials Consortium Study 31/ACTG A5349In a randomised, phase III treatment shortening trial for drug-susceptible pulmonary tuberculosis, we evaluated barriers and facilitators of adolescent participation in clinical trials. Using the capability, opportunity, motivation and behaviour model, we constructed interview guides, conducted interviews with principal investigators across two research consortia and analysed interview transcripts.
Joan Mangan

EP02-117-21-Exploring antagonism in anti-TB drugs using a hollow-fiber modelIsoniazid is part of the frontline anti-tuberculosis (TB) regimen. We have shown that its inclusion in a rifampicin/isoniazid dual therapy model increases the incidence of drug-tolerant, lipid-rich cells that stain as if respiring but with a compromised cell wall. This data is indicative of clearance antagonism occurring in TB chemotherapy.
Robert Hammond

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E-posters
EP03-Digital technology in the fight against TB
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EP03-Digital technology in the fight against TB
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All E-posters are accessible via the "E-posters" section of the conference platform until 30 November.

EP03-118-21-Implementation of artificial intelligence for presumptive TB screening in Nagpur, IndiaIntroduction of newer technologies such as artificial intelligence in detection of diseases including tuberculosis (TB) are being piloted for efficacy and effectiveness. One such tool - qXR - was implemented for chest x-ray screening followed by microbiological testing for confirmation of TB. Lessons learned from the pilot can be used for scale-up.
Shibu Vijayan

EP03-119-21-Decentralised drug-resistant TB treatment challenges in South Africa and options for implementation of a smartphone application based on latest guidelinesSouth Africa has the third highest number of notified cases of drug- resistant tuberculosis. We discuss use of behaviour change theory to understand key barriers to awareness of, and access to, new care and treatment guidelines, as well as the development of a novel point-of-care decision supporting smart phone application.
Susanne Luedtke

EP03-120-21-Disease patterns on computer-assisted chest radiography in a community-based prevalence survey for TBCommunity-wide active case finding (ACF) for tuberculosis (TB) is a proposed intervention to reduce the burden of the disease. Computer-assisted radiography is an essential tool in the ACF intervention and can potentially be used to screen for undiagnosed, non-communicable diseases. We described the observations from a prevalence survey in communities in Blantyre.
Hussein Twabi

EP03-121-21-Integrated digital adherence technologies for TB: determinants of technology-derived adherenceThe Integrated Digital Adherence Technology Initiative (IDAT) enroled 12,100 patients in various technologies - 99DOTS (directly observed treatment, short course), MERM (medication event reminder monitor system, and video observed therapy (VOT) - across eight districts and three states in India. Heterogeneity in the outcome measure of technology-derived adherence is observed with various systems, technology and temporal and patient-level factors, affecting DAT uptake and engagement. 
Sirisha Papineni

EP03-122-21-Implementing a referral system for drug-resistant TB patients to maximise treatment linkages to the public sector and minimise the treatment initiation time in Mumbai, IndiaAchieving early elimination requires a strong referral mechanism where patient and private hospitals engage throughout the treatment. PATH is collaborating with the Mumbai Corporation to link privately diagnosed drug-resistant tuberculosis patients to the public sector. Effective referral mechanism and implementation strategy has resulted in successful patient linkages to the public sector.
Dnyaneshwar Waman

EP03-123-21-Methods for estimating spatial and time-varying transmission patterns of TB in Espirito Santo, Brazil, between 2005-2013Tuberculosis (TB) case notification data is often collected for surveillance. We describe a method to estimate reproductive numbers with spatial variability using this data. We correlate estimated reproductive numbers in four municipalities in Espirito Santo, Brazil, with data from a concurrent household contact study and RFLP to understand transmission dynamics.

Benjamin Rader

EP03-124-21-eHealth in the future of TB medicines management: a case of a TB medicines web-based ordering and reporting system in UgandaIn developing countries, healthcare systems face major challenges with tuberculosis (TB) medicines management and reporting. Electronic TB medicines ordering and reporting systems facilitate information gathering for healthcare decision support by enhancing the speed and accuracy of data transmission and better stock monitoring, thus ensuring uninterrupted medicine availability.
Hawa Nakato

EP03-125-21-How can we find TB patients not linked to care? Lessons learned from a systematic tracing process implemented in the Western Cape Province, South AfricaTuberculosis (TB) case finding and treatment initiation is a major challenge in the Western Cape, South Africa. Linkage to care has individual benefits and reduces risk of onward transmission. Patient case finding requires use of different strategies, creativity and flexibility. 
Nosivuyile Vanqa

EP03-126-21-An assessment of the effectiveness of mobile community-based TB screening in Blantyre, Thyolo and Mwanza, in MalawiMobile van intervention has proved to be a viable strategy in finding missing active tuberculosis (TB) cases. All cases have been referred to the nearest hospitals for treatment and proper management. Sustainability of this intervention within the National TB Control Programme will see Malawi achieving its goal of ending TB infection in the country.
Allan Chimpeni

EP03-127-21-Decentralising access to digital information management to treatment supporters level for efficient real-time patient managementTreatment supporters (TS) counsel and follow up with TB patients until treatment completion. With Nikshay, India’s TB patient management system, treatment supporters can log in and update a TB patient’s health record. On treatment completion, the TS' honorarium can be processed digitally without delay.
Manu Easow Mathew

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EP04-Learning from epidemiological analyses
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EP04-Learning from epidemiological analyses
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All E-posters are accessible via the "E-posters" section of the conference platform until 30 November.

EP04-128-21-Results of pulmonary TB screening for the elderly aged ≥ 65 years in Korea, 2019The KCDC selected six regions with a high tuberculosis (TB) incidence rate in the elderly, aged 65 years or over, and conducted TB screening. The project aims to early detect and treat elderly TB patients and prevent TB transmission among the elderly population. This paper describes the study results.
Heeae Kim

EP04-129-21-Excess mortality in TB patients diagnosed at hospital vs at primary healthcare in South AfricaInitial loss to follow-up among tuberculosis (TB) patients is a significant gap in the TB cascade and includes pre-treatment mortality. We evaluated all TB patients diagnosed at primary healthcare, district or tertiary hospitals in two sub-districts of Cape Town. We identified predictors of mortality and demonstrated the time to death using survival analyses.
Muhammad Osman

EP04-130-21-A geo-epidemiological approach to diagnose social inequities among territories vulnerable to TB in the North-East of BrazilIdentify the social inequalities associated with the occurrence of tuberculosis in areas at risk of the disease. This is an ecological study. For the analyses, the statistical model called Generalised Additive Models for Location, Scale and Shape, was used.
Ricardo Arcêncio

EP04-131-21-Poor linkage to care and high mortality among pregnant women with TB in South AfricaThis study describes linkage to care and mortality among pregnant women diagnosed with tuberculosis (TB) in Cape Town, South Africa. Using routinely collected TB data, we describe this cohort of pregnant women with TB, stratified by location of diagnosis and hospital vs. primary health care facility. 
Sue-Ann Meehan

EP04-132-21-Individual associated factors for developing tuberculous meningitis: a cross-sectional studyDiagnosis of tuberculous meningitis (TBM) is challenging. We analysed the data of demographics, comorbidities and concurrent tuberculosis (TB) for TBM and non-TBM in patients from January 2008 to December 2019 in Beijing Chest Hospital (Beijing, China). Individual associated factors for developing TBM were identified by using univariate and multivariate logistic regression.
Mailing Huang

EP04-133-21-Prevalence and risk factors of active TB in Chinese rheumatic patients: a multicentre, cross-sectional studyA tertiary, hospital-based and multicentre cross-sectional study was conducted between September 2014 and September 2015. Eligible patients with confirmed diagnosis of various rheumatic diseases were consecutively recruited and screened for active TB. Calculation of prevalence and analysis of risk factors along with data about demographic features, underlying diseases and past and current medications were obtained.
Xiaoqing Liu

EP04-134-21-Geospatial determinants of TB active case finding among men and working age adults in Lima, PeruIn screening programmes for tuberculosis (TB), men and working age adults often have lower participation. In an active case finding programme for TB in Lima, Peru, we aimed to identify locations that had higher than average attendance by men and working age adults.
Helen Jenkins

EP04-135-21-Geospatial mapping of TB burden in Anambra State, South-East NigeriaWe conducted a geospatial mapping of all the notified tuberculosis (TB) cases in the state to enable a visualisation of hotspots of TB transmission to be targeted with case finding interventions. Patterns of TB burden across the state showed marked differences in urban areas between local government areas in the state. 
Chukwuebuka Ugwu

EP04-136-21-Factors associated with health seeking behaviour of people to be evaluated for TB aged 15 years and above in Indonesia: tuberculosis prevalence surveyThis paper aims to examine the health seeking behaviour of people to be evaluated for tuberculosis (TB). This study included adults to be evaluated for TB aged 15 years old and above based on the Indonesia TB prevalence survey, within the initial behaviour model. 
Permata Silitonga

EP04-137-21-Seasonality and trend of TB incidence rate after GeneXpert MTB/RIF era: a study in a vulnerable region from Brazilian Eastern AmazonEcological study in Macapá, capital of the state of Amapá, region of the Brazilian Eastern Amazon. We applied the interrupted time series method for diagnosing seasonality and the Prais-Winsten method to classify the event trend.
Ricardo Arcêncio

EP04-138-21-TB incidence rates and their determinants: an ecological multicountry analysis, 2005-2015The study identified three intermediary social determinants of health that were associated with changes in tuberculosis (TB) incidence rates across 115 countries between 2005 and 2015. Further action to address these determinants may help to achieve global goals in TB incidence reduction by 2035.
Fiona Alma Koeltringer

EP04-139-21-Risk factors for mortality among patients with multidrug-resistant TB in Uganda: a case-control studyRisk factors for mortality among patients with multidrug-resistant tuberculosis (MDR-TB) in Uganda: a case-control study for patients in the 2016 cohort using the long MDR-TB treatment regimen. This was done under programmatic conditions. 
Enock Kizito

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E-posters
EP05-Person-centred care: the advantages and challenges
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EP05-Person-centred care: the advantages and challenges
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EP05-140-21-Using patient pathway analysis in Rwanda: methods, problems and the importance of data and sensitivity analysisThis patient pathway analysis was done to inform the alignment between the availability of tuberculosis diagnostic and treatment services at facilities in Rwanda and care seeking behaviour towards these facilities.
Puck Pelzer

EP05-141-21-Improving surveillance data quality in Nikshay: introduction of machine assisted deduplicationAll healthcare providers in India, including laboratories and chemists, are required to notify cases of tuberculosis (TB) in Nikshay - the national TB surveillance system - increasing the risk of duplicate notifications. To prevent this, a machine-assisted deduplication mechanism has been developed, providing an approximate 25% positive predictive value.
Jyoti Jaju

EP05-142-21-The paradox of free TB care in private-for-profit private care facilitiesThe provision of a public health intervention within private-for-profit facilities is morally appealing but can be faced with the challenge of overhead costs. In the implementation of PPM-DOTs models, businesses' operational costs must be considered and incentive packages tailored to mitigate these costs as part of tuberculosis care service for sustainability.
Dziedzorm Awalime

EP05-143-21-Pillar Two of the End TB Strategy: impact of bold policies and supportive systems on programme implementation in IndiaArticle documents the improvement in coverage of nutritional support scheme as a result of intensive monitoring of the same, reiterating the need for adequate political commitment with adequate resources for a tuberculosis free world
Deepak Balasubramanian

EP05-144-21-Comparison and analysis of different mode of administration for TB treatment in Papua New GuineaThis study compares treatment outcomes in tuberculosis (TB) patients using three modes of administration (MOA), including directly observed treatment (DOT) by treatment supporters, self-administrated treatment (SAT), and family model (FM). We also assessed adherence in a small cohort of multidrug-resistant TB patients with SAT versus FM.
Rakhat Akmatova

EP05-145-21-Patient-centred TB treatment support tools: a mixed method, randomised controlled pilot study exploring initial efficacy and refinement needsWe present the initial assessment of the tuberculosis (TB) treatment support tools (TB-TSTs) intervention. TB-TSTs links a patient-centred mobile application, a paper-based drug metabolite urine test and interactive communication with a treatment supporter. The study was conducted within a public respiratory specialised reference hospital in Argentina.
Sarah Iribarren

EP05-146-21-Evaluation of the accuracy of 99DOTS digital adherence technology for TB in Metro Manila, PhilippinesThe accuracy of 99DOTS, a mobile phone digital adherence tool enabling remote monitoring of tuberculosis (TB) drug intake, was evaluated in a Metro Manila pilot. Results from 103 participants showed the following findings: PPV=97.9%, NPV=0.0% and sensitivity=94.1%. 99DOTS adherence is corroborated by the IsoScreen used to represent true adherence status.
Jason Alacapa

EP05-147-21-Fully oral rifampicin-resistant TB treatment regimens: progress in removing injectable agents from high TB burden country policiesWhile progress has been made in high tuberculosis (TB) burden countries towards policy guidance for shorter and longer all-oral rifampicin- resistant tuberculosis (RR-TB) regimens recommended by the World Health Organization, results from the #StepUpforTB 2020 study shows slow changes in phasing out injectable agent use for routine RR-TB treatment.  
Pilar Ustero

EP05-148-21-Patient-centred care for drug-resistant TB: responding to diverse clinical and social circumstancesSouth African healthcare remains poorly responsive to the socio-economic and psychological needs of patients. Patients experience complex medical and social challenges, which belie a one-size-fits-all model of care. Service delivery needs to be differentiated in order to better address specific needs and vulnerabilities of individual patients.
Leila Mitrani

EP05-149-21-Perspectives on access to TB health services in Shigatse, Tibet, ChinaA qualitative study exploring the experiences and perspectives of access to tuberculosis (TB) care among people living with TB in Shigatse, Tibet China. Ten semi-structured interviews were conducted with Tibetan interpretation as well as analysis using an access-to-care framework to conceptualise determinants of access to TB care.
Victoria Haldane

EP05-150-21-Beyond free medical care: why TB patients seeking treatment in national TB programme facilities still face catastrophic expenses in the Philippines?This study determines the drivers of costs faced by tuberculosis (TB) patients seeking treatment in government facilities. Using a cross-sectional survey of 1,880 TB patients, it provides an estimate of the proportion of TB-affected families facing catastrophic cost in the Philippines.
Rosa Mia Arao

EP05-151-21-Short- and long-term outcomes of video observed TB treatment among patients in Chisinau, the Republic of MoldovaVideo Observed Treatment (VOT) in addition to Directly Observed Treatment Strategy (DOT) was piloted in the Republic of Moldova. A study involved 83 tuberculosis patients on VOT and 86 on DOT. VOT reduced required time and travel costs for treatment while maintaining high levels of adherence and favourable treatment results.
Svetlana Doltu

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EP06-TB: data matters
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EP06-TB: data matters
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All E-posters are accessible via the "E-posters" section of the conference platform until 30 November. .

EP06-152-21-Assessment of TB underreporting by level of reporting system in Lagos, NigeriaAssessment of tuberculosis (TB) underreporting by level of reporting system, Nigeria. It was a quantitative, descriptive study using secondary data from an inventory study on TB reporting knowledge, attitude and behaviour conducted in 2017 in Lagos State to assess TB underreporting by type and level of health facilities, including associated factors.  
Mustapha Gidado

EP06-153-21-Improving TB treatment outcomes through effective linkage of transfer out patientsThe transfer out tool proved to be an effective strategy in referral and linkage for all tuberculosis (TB) patients who prefer continuum of care at facilities of their convenience. TB control programmes should consider adopting this tool and roll it out to all TB sites to improve quality of care. 
Stella Omulo

EP06-154-21-Nationwide surveillance of emerging isoniazid resistance after implementation of isoniazid preventive therapy for TB contactsAlthough population isoniazid resistance does not increase due to isoniazid preventive therapy, consider to provide isoniazid resistance as a priority of developing rapid drug susceptibility test for individuals who have developed TB after isoniazid preventive therapy can further advance propagation of prevention programme with trust.
Pei-Chun Chan

EP06-155-21-Review of the epidemiological mathematical modelling literature to inform TB vaccination development and strategiesMathematical models provide valuable information to aid the development of tuberculosis (TB) vaccines and vaccination strategies. Evaluating the impact of different vaccine characteristics in varied epidemiological settings such as exploring age, spatial hotspot and risk group targeting, as well as accounting for HIV, multidrug-resistance and population endemicity, can inform country-level implementation of novel TB vaccines.
Rebecca A. Clark

EP06-156-21-Strengthening hospital DOTS linkage using ad hoc staff to find missing TB cases: The Aminu Kano Teaching Hospital ExperienceAminu Kano Teaching Hospital (AKTH) is the largest tertiary facility in Kano state with an average daily hospital attendance of 862 patients. We sought to improve facility based active case finding by engaging trained ad hoc staff and deploying them across service delivery points over a period of time.
Mamman Bajehson

EP06-157-21-Incorporating patient reporting patterns to evaluate geographically targeted TB interventions in Dhaka, BangladeshTuberculosis (TB) is geographically heterogeneous and geographic targeting can improve the impact and efficiency of TB interventions. However, standard TB notification data may not sufficiently capture this heterogeneity. Better understanding of patient reporting behaviour may improve our ability to use notifications to appropriately target interventions.
Isabella Gomes

EP06-158-21-Lessons from a data quality assessment of TB notifications in Zambia: the case of under notification in a national TB programmeNational tuberculosis (TB) programmes should conduct periodic data quality assessments (DQAs) to validate notifications data. Findings will be very useful in designing future programming and implementation. The findings underscore the urgent need to strengthen the linkage to care. National TB programmes could potentially increase the TB treatment coverage by restoring data management systems.
Patrick Lungu

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E-posters
EP07-Improving TB care in children
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EP07-Improving TB care in children
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All E-posters are accessible via the "E-posters" section of the conference platform until 30 November.

EP07-159-21-Detecting and preventing paediatric TB through systematic household contact investigations in nine sub-Saharan countriesWe describe yields in tuberculosis (TB) detection and TB preventive therapy cascades - from screening to treatment completion - obtained during an intervention supporting systematic household contact investigation of paediatric TB index cases across nine sub-Saharan countries.
Jean-Francois Lemaire

EP07-160-21-Paediatric TB detection and treatment cascade in nine sub-Saharan countries following the CaP-TB interventionWe prospectively documented retention in the paediatric tuberculosis (TB) care cascade - from screening to treatment outcomes - during a comprehensive intervention, including paediatric specific systematic symptoms screening in health facilities, increased access to Xpert MTB/RIF testing, intensified household contact investigation and treatment of drug-sensitive TB with child-friendly formulations across nine sub-Saharan countries.
Shirin Kakayeva

EP07-161-21-Increasing paediatric TB detection and treatment in private health sector in IndiaWe share findings from the intervention on integrating comprehensive paediatric tuberculosis (TB) care cascade among private healthcare facilities in India. This includes evidence from intensified case finding activities in private facilities, enhancing their access to government’s free Xpert MTB/RIF diagnostics and WHO approved child-friendly fixed dose combination (FDC) dispersible drugs.
Karun Sandeep Veesa

EP07-162-21-Training physicians in India to interpret paediatric chest radiographs according to World Health Organization research methodologyChest radiography is the standard for diagnosing paediatric lower respiratory infections in low- and middle-income countries. Research in India required training local physicians to interpret chest radiographs following an updated World Health Organization interpretation method. We described the methodology for training Indian physicians and evaluated the training’s effectiveness.
Eric D McCollum

EP07-163-21-Care cascade of contact screening and preventive therapy among children under five in high-burden districts of NepalContact screening and provision of preventive therapy for under 5s as one intervention to prevent childhood TB in 38 high-burden districts of Nepal from 2017. Care cascade constructed in this paper focuses on contract tracing done during the period of March 2018-Dec 2019.
Suvesh Kumar Shrestha

EP07-164-21-Paediatric latent TB infection cascade of care from the TB and Leprosy Free Majuro community mass screening projectTB and Leprosy Free Majuro was a tuberculosis/latent tuberculosis infection (TB/LTBI) mass screening campaign implemented by the Republic of the Marshall Islands' Ministry of Health, on Majuro Atoll, from June to November 2018. It offered screening and treatment for LTBI in children 0-14 years old with varying success depending on age cohort.
Rachel Dwilow

EP07-165-21-Improvement of screening for childhood TB in Senegal coupled with screening for malnutrition: pilot study in the health districts of Thiès and Tivaouane, SénégalWe carried out operational research on the integration of the two tuberculosis (TB) and malnutrition control programmes to improve the screening of these diseases in children aged 0 to 14. This research developed by OMS/TDR shows that it can help the programme to improve the screening of childhood TB in Senegal.
Nafissatou Oumar Toure

EP07-166-21-Barriers to uptake of isoniazid preventive therapy among eligible child household contacts of TB patients in Southern NigeriaThis research explores the barriers to the uptake of isoniazid preventive therapy among eligible child contacts (under 6 years of age) of TB patients in six states of Southern Nigeria. Study findings highlight both patients and health systems factors.
Chukwuka Alphonsus

EP07-167-21-The state of paediatric, rifampicin-resistant TB in Khayelitsha, South AfricaOutcomes for paediatrics who receive rifampicin-resistant TB (RR-TB) treatment are excellent. Despite universal access to Xpert in South Africa, the frequency of paediatric cases detected has not increased, suggesting that diagnosis of RR-TB in paediatrics remains a challenge. Efforts to improve case detection, contact assessment and appropriate treatment initiation are urgently needed.
Johnny Daniels

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