Sessions

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Opening Ceremony: Marking The Union's Centennial Year
20 October 2020              2PM-3PM CEST
 
On 20 October 1920, representatives from 31 countries, recognising that a global health crisis – tuberculosis – could not be defeated without international collaboration and knowledge sharing, came together and founded The Union. One hundred years later, as the world struggles to confront a new infectious respiratory disease – COVID-19 – our founders’ vision remains as relevant as ever.

As The Union turns a century old, we also embark upon the first ever virtual Union World Conference. The opening ceremony will reflect on the journey so far and the distance left to travel.
 
We will hear from:
 - Her Imperial Highness Crown Princess Akishino of Japan
- President Bill Clinton
- World Health Organization Director-General Dr Tedros Adhanom Ghebreyesus
- Yvonne Chaka Chaka, singer, entrepreneur, Global Health Advocate and humanitarian
- Divya Sojan, TB survivor and nurse
- Shannon Hader, Deputy Executive Director United Nations Programme on HIV/AIDS (UNAIDS)
- Katherine Maher, Chief Executive of the Wikimedia Foundation (Interviewed by Noam Cohen, WIRED)
- Claire Forlani, UK Film and TV Actress, and The Union’s TB Ambassador
- Dr Tamaryn Green, TB Survivor, Medical Doctor, Miss South Africa 2018
 
President of The Union, Professor Guy Marks, The Union’s Executive Director, José Luis Castro, and Dr Keren Middelkoop, Chair Coordinating Committee of Scientific Activities will also speak.

Please join our opening ceremony and we wish you an inspiring virtual Union World Conference.

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Health advocacy for access to care
Alternative respond to Covid-19 by the Civil Society Organisations in South Africa

Please note that the number of participants is limited to 50 for this session.

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TB vaccine for children

Please note that the number of participants is limited for this session.

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All E-posters are accessible via the "E-posters" section of the conference platform until 30 November.

EP05-140-21-Using patient pathway analysis in Rwanda: methods, problems and the importance of data and sensitivity analysisThis patient pathway analysis was done to inform the alignment between the availability of tuberculosis diagnostic and treatment services at facilities in Rwanda and care seeking behaviour towards these facilities.
Puck Pelzer

EP05-141-21-Improving surveillance data quality in Nikshay: introduction of machine assisted deduplicationAll healthcare providers in India, including laboratories and chemists, are required to notify cases of tuberculosis (TB) in Nikshay - the national TB surveillance system - increasing the risk of duplicate notifications. To prevent this, a machine-assisted deduplication mechanism has been developed, providing an approximate 25% positive predictive value.
Jyoti Jaju

EP05-142-21-The paradox of free TB care in private-for-profit private care facilitiesThe provision of a public health intervention within private-for-profit facilities is morally appealing but can be faced with the challenge of overhead costs. In the implementation of PPM-DOTs models, businesses' operational costs must be considered and incentive packages tailored to mitigate these costs as part of tuberculosis care service for sustainability.
Dziedzorm Awalime

EP05-143-21-Pillar Two of the End TB Strategy: impact of bold policies and supportive systems on programme implementation in IndiaArticle documents the improvement in coverage of nutritional support scheme as a result of intensive monitoring of the same, reiterating the need for adequate political commitment with adequate resources for a tuberculosis free world
Deepak Balasubramanian

EP05-144-21-Comparison and analysis of different mode of administration for TB treatment in Papua New GuineaThis study compares treatment outcomes in tuberculosis (TB) patients using three modes of administration (MOA), including directly observed treatment (DOT) by treatment supporters, self-administrated treatment (SAT), and family model (FM). We also assessed adherence in a small cohort of multidrug-resistant TB patients with SAT versus FM.
Rakhat Akmatova

EP05-145-21-Patient-centred TB treatment support tools: a mixed method, randomised controlled pilot study exploring initial efficacy and refinement needsWe present the initial assessment of the tuberculosis (TB) treatment support tools (TB-TSTs) intervention. TB-TSTs links a patient-centred mobile application, a paper-based drug metabolite urine test and interactive communication with a treatment supporter. The study was conducted within a public respiratory specialised reference hospital in Argentina.
Sarah Iribarren

EP05-146-21-Evaluation of the accuracy of 99DOTS digital adherence technology for TB in Metro Manila, PhilippinesThe accuracy of 99DOTS, a mobile phone digital adherence tool enabling remote monitoring of tuberculosis (TB) drug intake, was evaluated in a Metro Manila pilot. Results from 103 participants showed the following findings: PPV=97.9%, NPV=0.0% and sensitivity=94.1%. 99DOTS adherence is corroborated by the IsoScreen used to represent true adherence status.
Jason Alacapa

EP05-147-21-Fully oral rifampicin-resistant TB treatment regimens: progress in removing injectable agents from high TB burden country policiesWhile progress has been made in high tuberculosis (TB) burden countries towards policy guidance for shorter and longer all-oral rifampicin- resistant tuberculosis (RR-TB) regimens recommended by the World Health Organization, results from the #StepUpforTB 2020 study shows slow changes in phasing out injectable agent use for routine RR-TB treatment.  
Pilar Ustero

EP05-148-21-Patient-centred care for drug-resistant TB: responding to diverse clinical and social circumstancesSouth African healthcare remains poorly responsive to the socio-economic and psychological needs of patients. Patients experience complex medical and social challenges, which belie a one-size-fits-all model of care. Service delivery needs to be differentiated in order to better address specific needs and vulnerabilities of individual patients.
Leila Mitrani

EP05-149-21-Perspectives on access to TB health services in Shigatse, Tibet, ChinaA qualitative study exploring the experiences and perspectives of access to tuberculosis (TB) care among people living with TB in Shigatse, Tibet China. Ten semi-structured interviews were conducted with Tibetan interpretation as well as analysis using an access-to-care framework to conceptualise determinants of access to TB care.
Victoria Haldane

EP05-150-21-Beyond free medical care: why TB patients seeking treatment in national TB programme facilities still face catastrophic expenses in the Philippines?This study determines the drivers of costs faced by tuberculosis (TB) patients seeking treatment in government facilities. Using a cross-sectional survey of 1,880 TB patients, it provides an estimate of the proportion of TB-affected families facing catastrophic cost in the Philippines.
Rosa Mia Arao

EP05-151-21-Short- and long-term outcomes of video observed TB treatment among patients in Chisinau, the Republic of MoldovaVideo Observed Treatment (VOT) in addition to Directly Observed Treatment Strategy (DOT) was piloted in the Republic of Moldova. A study involved 83 tuberculosis patients on VOT and 86 on DOT. VOT reduced required time and travel costs for treatment while maintaining high levels of adherence and favourable treatment results.
Svetlana Doltu

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All E-posters are accessible via the "E-posters" section of the conference platform until 30 November.

EP04-128-21-Results of pulmonary TB screening for the elderly aged ≥ 65 years in Korea, 2019The KCDC selected six regions with a high tuberculosis (TB) incidence rate in the elderly, aged 65 years or over, and conducted TB screening. The project aims to early detect and treat elderly TB patients and prevent TB transmission among the elderly population. This paper describes the study results.
Heeae Kim

EP04-129-21-Excess mortality in TB patients diagnosed at hospital vs at primary healthcare in South AfricaInitial loss to follow-up among tuberculosis (TB) patients is a significant gap in the TB cascade and includes pre-treatment mortality. We evaluated all TB patients diagnosed at primary healthcare, district or tertiary hospitals in two sub-districts of Cape Town. We identified predictors of mortality and demonstrated the time to death using survival analyses.
Muhammad Osman

EP04-130-21-A geo-epidemiological approach to diagnose social inequities among territories vulnerable to TB in the North-East of BrazilIdentify the social inequalities associated with the occurrence of tuberculosis in areas at risk of the disease. This is an ecological study. For the analyses, the statistical model called Generalised Additive Models for Location, Scale and Shape, was used.
Ricardo Arcêncio

EP04-131-21-Poor linkage to care and high mortality among pregnant women with TB in South AfricaThis study describes linkage to care and mortality among pregnant women diagnosed with tuberculosis (TB) in Cape Town, South Africa. Using routinely collected TB data, we describe this cohort of pregnant women with TB, stratified by location of diagnosis and hospital vs. primary health care facility. 
Sue-Ann Meehan

EP04-132-21-Individual associated factors for developing tuberculous meningitis: a cross-sectional studyDiagnosis of tuberculous meningitis (TBM) is challenging. We analysed the data of demographics, comorbidities and concurrent tuberculosis (TB) for TBM and non-TBM in patients from January 2008 to December 2019 in Beijing Chest Hospital (Beijing, China). Individual associated factors for developing TBM were identified by using univariate and multivariate logistic regression.
Mailing Huang

EP04-133-21-Prevalence and risk factors of active TB in Chinese rheumatic patients: a multicentre, cross-sectional studyA tertiary, hospital-based and multicentre cross-sectional study was conducted between September 2014 and September 2015. Eligible patients with confirmed diagnosis of various rheumatic diseases were consecutively recruited and screened for active TB. Calculation of prevalence and analysis of risk factors along with data about demographic features, underlying diseases and past and current medications were obtained.
Xiaoqing Liu

EP04-134-21-Geospatial determinants of TB active case finding among men and working age adults in Lima, PeruIn screening programmes for tuberculosis (TB), men and working age adults often have lower participation. In an active case finding programme for TB in Lima, Peru, we aimed to identify locations that had higher than average attendance by men and working age adults.
Helen Jenkins

EP04-135-21-Geospatial mapping of TB burden in Anambra State, South-East NigeriaWe conducted a geospatial mapping of all the notified tuberculosis (TB) cases in the state to enable a visualisation of hotspots of TB transmission to be targeted with case finding interventions. Patterns of TB burden across the state showed marked differences in urban areas between local government areas in the state. 
Chukwuebuka Ugwu

EP04-136-21-Factors associated with health seeking behaviour of people to be evaluated for TB aged 15 years and above in Indonesia: tuberculosis prevalence surveyThis paper aims to examine the health seeking behaviour of people to be evaluated for tuberculosis (TB). This study included adults to be evaluated for TB aged 15 years old and above based on the Indonesia TB prevalence survey, within the initial behaviour model. 
Permata Silitonga

EP04-137-21-Seasonality and trend of TB incidence rate after GeneXpert MTB/RIF era: a study in a vulnerable region from Brazilian Eastern AmazonEcological study in Macapá, capital of the state of Amapá, region of the Brazilian Eastern Amazon. We applied the interrupted time series method for diagnosing seasonality and the Prais-Winsten method to classify the event trend.
Ricardo Arcêncio

EP04-138-21-TB incidence rates and their determinants: an ecological multicountry analysis, 2005-2015The study identified three intermediary social determinants of health that were associated with changes in tuberculosis (TB) incidence rates across 115 countries between 2005 and 2015. Further action to address these determinants may help to achieve global goals in TB incidence reduction by 2035.
Fiona Alma Koeltringer

EP04-139-21-Risk factors for mortality among patients with multidrug-resistant TB in Uganda: a case-control studyRisk factors for mortality among patients with multidrug-resistant tuberculosis (MDR-TB) in Uganda: a case-control study for patients in the 2016 cohort using the long MDR-TB treatment regimen. This was done under programmatic conditions. 
Enock Kizito

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All E-posters are accessible via the "E-posters" section of the conference platform until 30 November.

EP02-110-21-International multicentre controlled trial to evaluate 1200mg and 1800mg rifampicin daily in the reduction of treatment duration for pulmonary TB from six to four monthsThe current treatment for drug-sensitive pulmonary tuberculosis (TB) involves taking drugs daily for six months. RIFASHORT is an international multicentre controlled clinical trial which evaluates higher doses of rifampicin with the objective of reducing the treatment duration for drug-sensitive pulmonary TB from six months to four months.
Tulika Munshi

EP02-111-21-Documenting challenges faced and lessons learned from implementation of STREAM – the world’s largest recruited multidrug-resistant TB clinical trialMulticountry clinical trial implementation is complex – from different regulatory requirements and approval processes to variable research infrastructure and capacity across settings. Here, we document challenges faced and lessons learned from STREAM – the first large-scale, multicountry clinical trial for multidrug-resistant tuberculosis.
Meera Gurumurthy

EP02-112-21-A method for baseline adjudication of TB diagnosis in children in a therapeutic clinical trial: experience from SHINEDiagnosing non-severe pulmonary tuberculosis (TB) in children is challenging.  Results in children adjudicated as having TB (in the SHINE trial comparing four vs six months of standard therapy) will be essential. The approach to adjudicate TB or not TB can help overcome challenges in paediatric TB studies in the absence of gold standard diagnostic tests.
Genevieve H Wills

EP02-113-21-Sustainability of the ACT4 randomised trial to improve initiation of TB preventive treatmentThe ACT4 randomised trial found that a health systems' intervention in strengthening management of latent tuberculosis (TB) infection was effective at increasing TB preventive therapy initiation rates in households contacts. In this follow up study, the sustainability of the ACT4 intervention was evaluated over the nine months following the end of the trial.
Olivia Oxlade

EP02-114-21-Utility of colour vision testing in screening for ethambutol-associated ocular toxicity in children treated for TB in the SHINE trialEthambutol-associated ocular toxicity (EAOT) is reported in 0.05-0.7% of children treated for tuberculosis (TB). Using a child-friendly colour vision test as a screening tool, there was no evidence of clinically significant EAOT in children taking ethambutol.  Colour vision testing in children is feasible but may not be necessary for standard drug-sensitive TB treatment.
Eric Wobudeya

EP02-115-21-Adolescents in a TB clinical treatment trial: characteristics of an under represented populationAdolescents represent approximately 10% of the global tuberculosis (TB) burden yet they are historically under represented in clinical trials, potentially limiting their access to new treatments. We examined enrolment patterns for adolescents in a TB Trials Consortium and AIDS Clinical Trials Group Phase III and rifapentine-containing treatment shortening trial for pulmonary TB (NCT02410772).
Kimberley Hedges

EP02-116-21-Investigator reported barriers and facilitators to adolescent recruitment, enrolment and retention in TB Trials Consortium Study 31/ACTG A5349In a randomised, phase III treatment shortening trial for drug-susceptible pulmonary tuberculosis, we evaluated barriers and facilitators of adolescent participation in clinical trials. Using the capability, opportunity, motivation and behaviour model, we constructed interview guides, conducted interviews with principal investigators across two research consortia and analysed interview transcripts.
Joan Mangan

EP02-117-21-Exploring antagonism in anti-TB drugs using a hollow-fiber modelIsoniazid is part of the frontline anti-tuberculosis (TB) regimen. We have shown that its inclusion in a rifampicin/isoniazid dual therapy model increases the incidence of drug-tolerant, lipid-rich cells that stain as if respiring but with a compromised cell wall. This data is indicative of clearance antagonism occurring in TB chemotherapy.
Robert Hammond

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All E-posters are accessible via the "E-posters" section of the conference platform until 30 November.

EP10-187-21-A missed opportunity: active contact investigation of diagnosed TB patients in NigeriaPeople who have been in close contact with bacteriologically confirmed pulmonary tuberculosis (TB) patients constitute a high-risk group for developing TB disease. Active household contact investigation of index TB patients demonstrates a great opportunity to increase a diverse pool of human resources, capacity to diagnosis and to notify additional TB cases.
Sani Useni

EP10-188-21-Risk of developing active multidrug-resistant TB among contacts in Taiwan, 2016-2018Identifying at-risk contacts, who have been exposed to a multidrug-resistant tuberculosis (MDR-TB) index patient, to see if they develop active disease would help advancing prevention of MDR-TB in Taiwan. In addition, active follow-up and prioritising those household or IGRA-positive contacts for latent TB treatment may further decline the incidence of MDR-TB. 
Pin Hui Lee

EP10-189-21-Utility of interferon gamma/tumor necrosis factor alpha FluoroSpot assay in differentiation between active TB and latent TB infection: a pilot studyWe aimed to provide a highly sensitive and practical auxiliary method for tuberculosis (TB) differential diagnosis. In this abstract, we demonstrated the diagnostic accuracy of the interferon gamma/tumor necrosis factor alpha (IFN-γ/TNF-α ) FluoroSpot assay for differentiating active TB from latent TB infection. 
Ziyue Zhou

EP10-190-21-Results of management latent TB infection in Quang Nam province, Viet Nam, 2017-2018Results of the management of latent tuberculosis (TB) infection during the period of 2017-2018 in Quang Nam province, Viet Nam. Interventions have shown to be effective in increasing the ability to identify, screen TB and treat latent TB infection among household contacts of TB patients.
LV Vinh

EP10-192-21-Effectiveness of contact tracing intervention for improving TB case detection in NigeriaSystematic investigation of contacts of index TB cases for active disease has remained a priority active case finding strategy. Stakeholders for tuberculosis (TB) control need to apply the right strategy, job aid, tools and training for health workers to help standardise TB information and empower communities with the right TB knowledge
Chidubem Ogbudebe

EP10-193-21-Dilemma in contact investigation: to expand or notContact investigation as a part of Dutch tuberculosis (TB) policy aims for early case detection, treatment and prevention of TB transmission. Risk assessment forms a basic approach to the organisation of contact investigation.
Sophie Toumanian

EP10-194-21-Piloting a shortened regimen for the treatment of latent TB infection in two provinces of Viet NamIn 2019, Friends for International TB Relief, together with the Viet Nam National TB Programme, implemented community-based tuberculosis (TB) case finding campaigns with integrated latent TB infection testing and treatment using a shortened regimen in two provinces of Viet Nam. We herein describe the results of these activities.
Thuy Thu Thi Dong

EP10-195-21-Prevalence of latent TB infection and predictive factors among working-age population in urban and rural area of Northern Guangdong, China: a cross-sectional studyChina has one of the highest burdens of latent tuberculosis (TB) infection (LTBI). Studies, which mainly focused on high-risk population, observed LTBI prevalence ranging from 9% up to 70%. The goal of this study was to describe LTBI burden in the general population, especially in those of working age, and determine its associated factors.
Fangjing ZHOU

EP10-196-21-Impact of civil society advocacy on the introduction of TB LAM testing in PEPFAR-eligible countriesUptake of tuberculosis (TB) LAM testing in high TB and HIV burden countries has been limited despite a demonstrated mortality benefit among people with advanced HIV. We reviewed FY2018 and FY2019 PEPFAR country operational plans to evaluate the impact of advocacy on TB LAM uptake in PEPFAR-eligible countries.
David Branigan

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All E-posters are accessible via the "E-posters" section of the conference platform until 30 November.

EP08-168-21-TB and Covid-19: Bangladesh perspective and challengesCovid-19 posed challenges in tuberculosis (TB) control in Bangladesh. During the first two months of the pandemic, a decrease in TB patients was reported. Patient-centred care was ensured by providing medicine to the patients and using telecommunication. Interim and long-term preparedness is required to resume enhanced momentum of TB control.
Mahfuza Rifat

EP08-169-21-The impact of Covid-19 on TB control in the Coast General Teaching and Referral Hospital, Mombasa County, KenyaKenya confirmed its first case of Covid-19 on 12 March 2020. In an effort to combat the pandemic Kenya, like the rest of the world, introduced some changes to its health service delivery. Being a country with a high tuberculosis (TB) burden, this had an impact on TB patients accessing care.
Cosmas Mwashumbe

EP08-170-21-Design and organisation of a temporary intensive care ward in response to the COVID-19 pandemicCOVID-19 placed a heavy burden on medical services. We designed and organised a temporary intensive care unit (ICU) ward within 48 hours. The space design, environmental cleaning and patients' daily care were the key steps to organising a practical ICU ward during the COVID-19 pandemic.
Xiangfeng Li

EP08-171-21-Trend analysis of exponential increase of COVID-19 cases in PakistanThe study was conducted to see the trends of COVID-19 among the Pakistani population. Pakistan started to feel the impact of the outbreak in mid-March with an increase in the number of cases at an alarming pace. So far, Sindh and Punjab province are the worst hit provinces with wide-spread community transmission.
Nadia Noreen

EP08-172-21-Sustaining TB services during the COVID-19 pandemic: experience and lessons learned from Nigeria in 2020Measures put in place to control the COVID-19 pandemic had the potential for interrupting tuberculosis (TB) services and erasing the gain made in TB control. Sustaining TB programmes during the COVID-19 pandemic became a priority of the national TB programme in Nigeria and the steps taken are documented and described in this study. 
Fadare Amos Omoniyi

EP08-175-21-Psychological experiences of mobile van TB screening team during COVID- 19 pandemic in Blantyre, MalawiResults have shown that health workers, working under MDU, experience several psychological challenges in this era of the COVID-19 pandemic and have compromised TB screening services. Therefore, mental health interventions are needed to mitigate these challenges. Self-coping style and psychological growth are important for health workers to maintain mental health.
Khwima Esther Mkalira

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All TBScience 2020 E-posters will be displayed from 10 am Central European Summer Time (CEST), on Wednesday, 21 October for the duration of the conference and beyond

EP-TBS-01-Increased neutrophil count and decreased neutrophil CD15 expression correlate with TB disease severity and treatment response
Lerato Ndlovu

EP-TBS-02-Genome-wide identification of Mycobacterium tuberculosis genetic markers associated with the history of BCG vaccination
Kamela Charmaine S. Ng

EP-TBS-03-Characterization of regulatory B-cells for tuberculosis management
Irene Latorre

EP-TBS-04-Different antimycobacterial activity of alveolar macrophages in various lung legions of tuberculosis patients
Sergey Skornyakov

EP-TBS-05-Plasma mediators of phagocytosis in tuberculosis patients during anti-TB treatment and zinc supplementation
Victory Edem

EP-TBS-06-Discerning divergent tuberculosis endotypes: A meta-analysis of individual patient data
Andrew DiNardo

EP-TBS-07-Plasma Interferon (IFN)-g Inducible Protein 10 (IP-10) levels but not the QuantiFERON Gold plus assay correlate with disease severity and paradoxical reactions in extrapulmonary tuberculosis
Isabelle Suarez

EP-TBS-08-Host immune factors related to non-multidrug resistant tuberculosis with treatment history in Vietnam
Naoto Keicho

EP-TBS-09-Risk factors for the development of tuberculosis in children with chronic non-specific lung diseases.
Sofya Nakonechnaya

EP-TBS-10-Polyfunctional T-cells and IL-2 production decrease during pregnancy in women with latent TB infection
Jyoti Mathad

EP-TBS-11-Neutrophils Contribute to Tuberculosis-linked Inflammation and lung pathology
Caleb Nwongbouwoh Muefong

EP-TBS-12-Association of neutrophil-derived inflammatory mediator levels with lung pathology in active tuberculosis at diagnosis
Caleb Nwongbouwoh Muefong

EP-TBS-13-Characterising the BCG-induced antibody response for antigen discovery
Rachel Tanner

EP-TBS-14-ESAT-6 / CFP-10-stimulated metabolic activity of pleural fluid cells if cured tuberculosis or TB / HIV
Sergey Skornyakov

EP-TBS-15-Blood-Based Biomarkers of Tuberculosis in Children Integrating Metabolomic and Transcriptomic Data
Jeffrey A Tornheim

EP-TBS-16-Identification of TGF-β1 in pleural tuberculosis: the possible role in fibrosis
Silvio Renan Pinheiro Victor de Araújo

EP-TBS-17-Analysis of serum microRNAs as pulmonary tuberculosis biomarkers
JaeIn Jung

EP-TBS-18-Up-regulated programmed death protein 1 expression on CD4 T cells in patients with MDR-TB  associated with lung lesion and mycobacterial load
Qi Tan

EP-TBS-19-Malnutrition affects levels of vascular endothelial growth factor levels among children and adolescents with pulmonary tuberculosis?
Caio Pluvier Duarte Costa

EP-TBS-20-Towards identification of protein markers of Mycobacterium tuberculosis H37Rv extracellular vesicles (EV)
MEHALENE JAYARAM

EP-TBS-21-Increased frequency of CD39+ regulatory T cells in the pleural fluid of patients with Tuberculosisin comparison to other exudative causes
Ana Paula Santos

EP-TBS-22-Longitudinal analysis of M. tuberculosis-specific T cell responses demonstrates dynamic T cell responses to ESAT-6 and CFP-10 during pregnancy independently of mitogen responses.
Aparajita Saha

EP-TBS-23-Serum Cytokine Profile as Biomarker for Multi-drug Resistant Tuberculosis
Alahaman Nana Boakye

EP-TBS-24-Reanalysis and validation of Tuberculosis genes signature in blood and pleural fluid from patients with exudative pleural effusion
Raquel da Silva Corrêa

EP-TBS-25-TimBre, Cough based screening of Pulmonary Tuberculosis using Machine Learning that is Explainable and Interpretable
Rahul Pathri

EP-TBS-26-HbA1C as prognostic factor in PTB
Sarang Patil

EP-TBS-27-Better intradermal delivery for bacille Calmette-Guérin (BCG) vaccine by microneedles in healthy adults of S. Korea
Hyejon Lee

EP-TBS-28-MULTIPLEX BIOMARKER ASSAY FOR DETECTION OF MYCOBACTERIUM TUBERCULOSIS
Puneet Gupta

EP-TBS-29-Role of the chemokine receptor CXCR3 in the recruitment and retention of lung resident memory T cells following a pulmonary TB vaccine. 
Warwick Britton

EP-TBS-31-Benefit of Quantiferon-TB Gold plus in incidence of TB disease in Heath care workers of Central Chest Institute of Thailand
piamlarp sangsayunh

EP-TBS-32-The blood monocyte/lymphocyte, neutrophil/lymphocyte and platelet/lymphocyte ratios in children with pulmonary tuberculosis
Larissa Gorbach

EP-TBS-33-Pulmonary tuberculosis patients have an anaerobe-enriched microbiota associated with a pro-inflammatory peripheral host immune phenotype
Charissa Naidoo

EP-TBS-34-The epidemiologic impact and cost-effectiveness of new tuberculosis vaccines on rifampicin resistant and multidrug resistant tuberculosis in India and China
Chathika Weerasuriya

EP-TBS-36-Novel, culture-free, same-day TB diagnosis with ultrasensitive ELISA
Rikiya Takeuchi

EP-TBS-37-Tuberculosis screening in point-of-care settings: Proof-of-concept for a fast and easy sample-to-answer qPCR-based protocol
Alexandre Dias Tavares Costa

EP-TBS-38-Diagnostic accuracy of three urine lipoarabinomannan tuberculosis assays in HIV-negative outpatients
Tobias Broger

EP-TBS-39-To Study The Presence Of Live Mycobacterium Tuberculosis In Resected Lung Specimens Of Patients Undergoing Lung resection Surgery For Post-Tuberculosis Sequelae
Pallavi Purwar

EP-TBS-40-What can tuberculosis prevalence surveys tell us about the duration of asymptomatic bacteriologically-positive disease?
Chu-Chang Ku

EP-TBS-41-An RNA signature for tuberculosis risk in pregnant women: a prospective cohort study from India
Jyoti Mathad

EP-TBS-42-Analysis of mycobacterial trans-renal DNA for the diagnosis of Tuberculous Meningitis in adults.
Manisha Dass

EP-TBS-43-Developing a tool to identify and screen Latent Tuberculosis Infection (LTBI) with likelihood of progression to active Tuberculosis (ATB)
Prashant Singh

EP-TBS-44-QuantiFERON TB plus-negative results in clinically diagnosed paediatric tuberculosis: immune suppression or misdiagnosis?
Gloria Ivy Mensah

EP-TBS-45-Evaluation of a blood-based antigen test for tuberculosis in HIV-exposed children younger than 5 years
Tony Hu

EP-TBS-46-Adverse drug reactions in MDR TB Patients on ATT
Sarang Patil

EP-TBS-47-Species and Drug Susceptibility profile of Non-tuberculous Mycobacteria isolated from presumptive TB cases
PRIYA RAJENDRAN

EP-TBS-48-MAMA-PCR assay for the detection of point mutations associated with drug resistance in Mycobacterium tuberculosis clinical isolates
Raquel Muñiz-Salazar

EP-TBS-49-Genomic diversity in Mycobacterium tuberculosis from human lung resections reveals a high degree of multiclonal infections in a high-burden MDR-TB setting
Miguel Moreno-Molina

EP-TBS-50-Pathogen genome sequencing to guide treatment regimen designs for multidrug-resistant tuberculosis
Hans-Peter Grobbel

EP-TBS-51-An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosis
Victoria Furió

EP-TBS-52-Antibiotic Resistance Profile Determination Using Whole Genome Sequencing
Ryan Howard

EP-TBS-53-Rapid genomic drug resistance prediction from clinical Mycobacterium tuberculosis specimens using amplicon based deep sequencing based on Deeplex-MycTB
Stefan Niemann

EP-TBS-54-Multi-resistant tuberculosis and HIV infection in Kinshasa: 2011-2018. DRC “Epidemiological, clinical and therapeutic aspects”
Nicole ANSHAMBI

EP-TBS-55-Long Read DNA Sequencing of XDR/MDR Tuberculosis Samples to Investigate Factors Leading to Resistance and Virulence
Michael Harris

EP-TBS-56-Genome-wide detection of epistasis in antibiotic resistant M. tuberculosis
Anna Green

EP-TBS-57-Population structure, biogeography and transmissibility of Mycobacterium tuberculosis
Luca Freschi

EP-TBS-58-Safety and Efficacy of an MDR-TB All-oral Short-course Regimen in China: An Preliminary Analysis of the MDR-Chi clinical trial
Liang Fu

EP-TBS-59-Drug exposure and minimum inhibitory concentration predict pulmonary tuberculosis treatment response
Xubin Zheng

EP-TBS-60-A novel therapeutic vaccine against multi-drug resistant tuberculosis by T cell-immunity in phase 1 clinical trial.
Masaji Okada

EP-TBS-61-Improving the safety of TB therapy with novel diagnostic biomarkers of liver toxicity – a study in UK and Ugandan patients
Derek Sloan

EP-TBS-62-Tuberculosis meningitis mouse model
Tuhina Gupta

EP-TBS-63-Pharmacokinetics of the three-drug fixed-dose dispersible tablet in children
Aziza Pakhlavonova

EP-TBS-64-Does BCG Vaccination protect against infection with Mycobacterium tuberculosis in Vietnamese schoolchildren?
Puck Pelzer

EP-TBS-65-Time to positivity as a surrogate biomarker of time to culture conversion
Belén P. Solans

EP-TBS-66-Use of the contact management register to identify those with Active and Latent TB, Kenya, Jan-March 2020
RHODA POLA

EP-TBS-67-Predicting Efficacy Outcome of Nine Tuberculosis Drugs in Phase 2a First-in-patients Studies
Nan Zhang

EP-TBS-69-Predicting optimal treatment durations for tuberculosis patients: a risk stratification algorithm and clinical simulation tool
Marjorie Imperial

EP-TBS-70-Adverse Drug Reactions in MDR TB Patients on Category IV Regimen in Western Odisha
SUMAN KUMAR JAGATY

EP-TBS-71-The effect of antiretroviral therapy and preventive tuberculosis therapy with anti-TB drugs on the duration of TB remission in HIV-infected patients
Igor Medvinskiy

EP-TBS-72-A Urine Colorimetric Assay for Levofloxacin Concentrations and Optimized Regimen Development
Prakruti Rao

EP-TBS-73-Development and Application of an Integrated Biomarker - Clinical Endpoint Tool for Late Stage TB Regimen Development and Clinical Trial Design
Marjorie Imperial

EP-TBS-74-Leveraging Neural Networks and Imaging Experts in Loops for Automated Tuberculosis Screening Using Chest Radiographs in Population Screening Programs to ensure efficient workflows.
Amit Kharat

EP-TBS-75-A model for the integration of traditional medicine into conventional medicine for the treatment of Tuberculosis (TB) in Zimbabwe
Winnet Enerita Chipato

EP-TBS-76-Point-of-Care Saliva Assay for Levofloxacin Concentrations and Personalized Dosing in Patients with Multidrug-Resistant Tuberculosis in Tanzania
Sagal Mohamed

EP-TBS-77-PBPK Model Informed Prediction to Evaluate the Effect of Renal Impairment and OCT genotypes on the Ethambutol Disposition
Yumi Park

EP-TBS-78-Development of Population Pharmacokinetic Model of the First-line anti-TB drugs in Korean patients with TB for Therapeutic Drug Monitoring Guided Dose Adjustment
Yumi Park

EP-TBS-79-Model Informed Personalized Dosing Algorithm Development for TB Therapy in Center for Personalized Precision Medicine (cPMTb)
Yumi Park

EP-TBS-80-Classifying adherence trajectories: an innovative tool for​ regimen development
Stephanie Law

EP-TBS-81-Predicting pretomanid penetration into patient lesions of tuberculosis
Jacqueline Ernest

EP-TBS-82-Rifapentine pharmacokinetics and pharmacodynamics: murine and human models to identify optimal dosing for treatment of latent M. tuberculosis infection
Jacqueline Ernest

EP-TBS-83-SLCO1B1 and SLC10A1 polymorphism and plasma rifampin concentrations in patients with co-morbidity tuberculosis-diabetes mellitus in Baja California, Mexico
Ricardo Perea-Jacobo

EP-TBS-84-Individual-Level Data Meta-Analysis of Adverse Events from Clinical Trials of Drug Sensitive Tuberculosis Treatment Regimens
Leah Jarlsberg

EP-TBS-85-G-clamp-inspired ligands and their effects on G-quadruplexes from Mycobacterium tuberculosis
Egor Shitikov

EP-TBS-86-Prediction of early bacterial activity (EBA) of bedaquiline in tuberculosis
Federico Romano

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EP07-159-21-Detecting and preventing paediatric TB through systematic household contact investigations in nine sub-Saharan countriesWe describe yields in tuberculosis (TB) detection and TB preventive therapy cascades - from screening to treatment completion - obtained during an intervention supporting systematic household contact investigation of paediatric TB index cases across nine sub-Saharan countries.
Jean-Francois Lemaire

EP07-160-21-Paediatric TB detection and treatment cascade in nine sub-Saharan countries following the CaP-TB interventionWe prospectively documented retention in the paediatric tuberculosis (TB) care cascade - from screening to treatment outcomes - during a comprehensive intervention, including paediatric specific systematic symptoms screening in health facilities, increased access to Xpert MTB/RIF testing, intensified household contact investigation and treatment of drug-sensitive TB with child-friendly formulations across nine sub-Saharan countries.
Shirin Kakayeva

EP07-161-21-Increasing paediatric TB detection and treatment in private health sector in IndiaWe share findings from the intervention on integrating comprehensive paediatric tuberculosis (TB) care cascade among private healthcare facilities in India. This includes evidence from intensified case finding activities in private facilities, enhancing their access to government’s free Xpert MTB/RIF diagnostics and WHO approved child-friendly fixed dose combination (FDC) dispersible drugs.
Karun Sandeep Veesa

EP07-162-21-Training physicians in India to interpret paediatric chest radiographs according to World Health Organization research methodologyChest radiography is the standard for diagnosing paediatric lower respiratory infections in low- and middle-income countries. Research in India required training local physicians to interpret chest radiographs following an updated World Health Organization interpretation method. We described the methodology for training Indian physicians and evaluated the training’s effectiveness.
Eric D McCollum

EP07-163-21-Care cascade of contact screening and preventive therapy among children under five in high-burden districts of NepalContact screening and provision of preventive therapy for under 5s as one intervention to prevent childhood TB in 38 high-burden districts of Nepal from 2017. Care cascade constructed in this paper focuses on contract tracing done during the period of March 2018-Dec 2019.
Suvesh Kumar Shrestha

EP07-164-21-Paediatric latent TB infection cascade of care from the TB and Leprosy Free Majuro community mass screening projectTB and Leprosy Free Majuro was a tuberculosis/latent tuberculosis infection (TB/LTBI) mass screening campaign implemented by the Republic of the Marshall Islands' Ministry of Health, on Majuro Atoll, from June to November 2018. It offered screening and treatment for LTBI in children 0-14 years old with varying success depending on age cohort.
Rachel Dwilow

EP07-165-21-Improvement of screening for childhood TB in Senegal coupled with screening for malnutrition: pilot study in the health districts of Thiès and Tivaouane, SénégalWe carried out operational research on the integration of the two tuberculosis (TB) and malnutrition control programmes to improve the screening of these diseases in children aged 0 to 14. This research developed by OMS/TDR shows that it can help the programme to improve the screening of childhood TB in Senegal.
Nafissatou Oumar Toure

EP07-166-21-Barriers to uptake of isoniazid preventive therapy among eligible child household contacts of TB patients in Southern NigeriaThis research explores the barriers to the uptake of isoniazid preventive therapy among eligible child contacts (under 6 years of age) of TB patients in six states of Southern Nigeria. Study findings highlight both patients and health systems factors.
Chukwuka Alphonsus

EP07-167-21-The state of paediatric, rifampicin-resistant TB in Khayelitsha, South AfricaOutcomes for paediatrics who receive rifampicin-resistant TB (RR-TB) treatment are excellent. Despite universal access to Xpert in South Africa, the frequency of paediatric cases detected has not increased, suggesting that diagnosis of RR-TB in paediatrics remains a challenge. Efforts to improve case detection, contact assessment and appropriate treatment initiation are urgently needed.
Johnny Daniels