19 October-1 December 2020
The 51st Union World Conference On Lung Health
REGISTER NOW

Sessions

All Sessions
keyboard_arrow_down
keyboard_arrow_down Show filters keyboard_arrow_up Hide filters
  • All Tracks
  • Community Connect
  • Channel 1
  • Channel 2
  • Channel 3
  • Channel 4
  • Channel 5
  • Channel 6
  • Channel 7
  • E-posters
  • Workshops
Channel 6
OA-11-New solutions to old TB challenges
event_note
Loading...
query_builder 11:00 - 12:20 | Event time (GMT+2)
query_builder - | Your time (GMT)
place Online Session/Virtual
card_travel Oral Abstract session
mic English
OA-11-New solutions to old TB challenges
*Please scroll down for more information*


11:00 - 11:05: Introduction


11:05 - 11:13: OA-11-563-22-Comparison of three bacteriological methods of Mycobacterium tuberculosis in cerebrospinal fluid Detection of cell-free DNA of pathogens has got good results in the diagnosis studies of various diseases. We prospectively detect the cell-free DNA of Mycobacterium tuberculosis (MTB), culture and Xpert MTB/RIF in cerebrospinal fluid of patients with tuberculous meningitis (TBM) and evaluated the diagnostic value of this three methods for TBM.

Xuelian Li

11:13 - 11:21: OA-11-564-22-Non-invasive respiratory aerosol sampling using masks for detection of pulmonary TB in children The development of a non-invasive sampling method for paediatric tuberculosis (TB) diagnosis is a priority research area. Respiratory aerosols collected on patients masks can be a simple and non-invasive source for diagnosis. This study provides a proof of concept that respiratory aerosols can be used for detection of pulmonary TB in children.

Kalpana Sriraman

11:21 - 11:29: OA-11-565-22-Stool-based Xpert Ultra testing for childhood TB in Kampala, Uganda We evaluated the performance of a centrifuge-free, rapid stool processing kit for the diagnosis of pulmonary tuberculosis in children using the Xpert MTB/RIF Ultra assay. We present the diagnostic accuracy among children prospectively enrolled in Kampala, Uganda, and added yield with a repeat test.

Mariam Nakabuye

11:29 - 11:37: OA-11-566-22-Development of a treatment decision algorithm for HIV-uninfected children with presumptive pulmonary TB We developed treatment decision algorithms and demonstrated that, clinical history and examination, provides sufficient evidence to make a treatment decision for pulmonary tuberculosis (TB) without chest radiography and Xpert. Starting more children on anti-TB treatment, based on clinical evidence, will contribute substantially to reducing TB mortality in children globally.

Kenneth Gunasekera

11:37 - 11:45: OA-11-567-22-Evaluation of mycobacterial smart probes: novel fluorescent probes for the detection of live mycobacteria in diagnostic samples The study focuses on the development of a new method for rapid screening of tuberculosis (TB) - new fluorescent dyes incorporated into the mycobacteria cell wall. At the University of Edinburgh, novel trehalose-based fluorescent probes (mycobacterial smart probes) were developed and evaluated in CTRI (Moscow, Russia).

Assel Baibek

11:45 - 11:53: OA-11-568-22-Identification and validation of efflux pump inhibitors against Rv1218c in multidrug-resistant TB clinical isolates To prevent resistance mediated by efflux pumps, designing inhibitors which in turn increases the activity of the antibiotics. Rv1218c is a major ABC transporter which causes efflux of multiple substrates, novobiocins and pyridines. We identified raffinose and palmitic acid as a potent efflux pump inhibitor, reducing the MICs of RMP.

Rajesh Mondal

11:53 - 12:20: Q&A


Loading...
E-posters
EP27-Difficult problems in TB infection and treatment
event_note
Loading...
query_builder 10:00 - 11:00 | Event time (GMT+2)
query_builder - | Your time (GMT)
place Online Session/Virtual
card_travel E-poster session
mic English
EP27-Difficult problems in TB infection and treatment
*Please scroll down for more information*
All E-posters are accessible via the "E-posters" section of the conference platform until 30 November.

EP27-354-23-Difference in persistent TB bacteria between in vitro and sputum from patients: implications for translational predictionsThis abstract covers work that revealed difference in phenotypic resistance between in vitro and in human tuberculosis patients, prior to initiation of chemotherapy. The findings will have impact on the prediction of EBA activity from in vitro, drug-effect experiments.
Alan Faraj

EP27-355-23-Characterisation of the metabolic urine profile using nuclear magnetic resonance spectroscopy to monitor treatment of TBEarly tuberculosis (TB) diagnosis in children is crucial for prescribing prompt treatment and reducing mortality. We identified a correlation between the nuclear magnetic resonance-based urinary metabolic profile and the standardised case definitions for TB diagnosis in children, which may improve childhood TB detection by shortening the time of diagnosis and initiation of treatment.
Patricia Comella-del-Barrio

EP27-357-23-Systemic inflammation in pregnant women with and without latent TB infectionStudies have reported increased systemic inflammation in adults with latent tuberculosis infection (LTBI+) compared to those without LTBI. However, as potential differences have not been assessed in pregnant populations, we compared levels of systemic inflammation by LTBI status in pregnant women with, and without, LTBI in Pune, India. 
Rupak Shivakoti

EP27-359-23-Predicting the efficiency of the treatment of drug-resistant TB depending on the polymorphism variation of glutathione-S-transferase genesGenes, the expression of which plays a key role in the resistance of cells to the effects of free radicals by lipid peroxidation and oxidative modification of proteins, preventing breakage of DNA, biosynthesis of prostaglandins, transportation and metabolism of bilirubin, hormones are genes which code the synthesis of glutathione-S -transferase.
Ihor Semianiv

EP27-360-23-Usefulness of gene sequencing for identification of non-tuberculous mycobacteriaCorrect identification is crucial to manage non-tuberculous mycobacteria (NTM) infection. Line probe assays are widely used for identification of NTM, but they cover 20-30 species. Our study showed that 16S rRNA and rpoB gene sequencing were able to give a species name for most isolates not identified by line probe assay.
Chang-Ki Kim

EP27-362-23-Latency-associated antigen Rv1733c of Mycobacterium tuberculosis improves the value of differential diagnosis of active TB and latent TB infectionCurrently available interferon-γ release assay cannot reliably differentiate active tuberculosis (ATB) from latent tuberculosis infection (LTBI). Our research shows that Rv1733c SLP can be used as an alternative antigen for T cell-based TB diagnostic tests, in combination with ESAT-6 and CFP-10, to conducive differentiate between ATB and LTBI.
Huimin Ma

EP27-363-23-Dried blood spot sampling to assess rifampicin pharmacokinetics among TB patients in Paraguay: native indigenous and general populationA minimally invasive, alternative sampling matrix collected utilising limited sampling time points has gained significant traction with a potential to make therapeutic drug monitoring an attainable goal in settings with tuberculosis (TB) endemicity. We evaluated rifampicin pharmacokinetic parameters, among native indigenous and general Paraguayan TB patients, using dried blood spots sampling. 
Samiksha Ghimire

Loading...
E-posters
EP32-Quality improvement of the TB cascade of care
event_note
Loading...
query_builder 10:00 - 11:00 | Event time (GMT+2)
query_builder - | Your time (GMT)
place Online Session/Virtual
card_travel E-poster session
mic English
EP32-Quality improvement of the TB cascade of care
*Please scroll down for more information*
All E-posters are accessible via the "E-posters" section of the conference platform until 30 November.

EP32-404-24-Evaluation of TB active case finding cascade: results from a TB surge intervention in Akwa Ibom State, NigeriaActively finding tuberculosis through screening of all hospital attendees and instituting multiple testing options, will widen the chances of finding the missing cases within the health facility. Due to poor health-seeking behaviour and lack of awareness, most persons will not seek medical attention because of a cough.
Ifiok Ekanim

EP32-405-24-Pay for performance to optimise the TB care cascade and improve quality of services at high volume health facilities in KenyaThrough Global Fund support, Amref Health Africa - in collaboration with the national tuberculosis (TB) programme in Kenya - is implementing a pay for performance initiative in 197 high volume health facilities in 13 high TB burden counties. Facilities earn money for additional TB cases notified and quality of TB services offered. 
Anne Gorreti Munene

EP32-406-24-Cascade analysis for active TB case finding intervention in Nigeria: a tool for quality improvement and programme monitoringKNCV Nigeria constructed a cascade to assess clients’ retention across tuberculosis (TB) screening stages. Based on epidemiological data, we set targets for each stage and designed a template for weekly data monitoring and cascade analysis to measure gaps. We did root cause analysis and designed specific interventions to address identified gaps.
Ogoamaka Chukwuogo

EP32-407-24-Impact of TB cascade loss in a facility-based, intensified TB case finding intervention in Nasarawa State, NigeriaThe review of the impact of loss of patients in a cascade during facility-based screening activities has the potential to undermine efforts to find missing tuberculosis (TB) cases in Nigeria. This can lead to programmatic under-reporting and an increase in the spread of TB in communities
Daniel Egbule

EP32-408-24-Implementation and scale-up of TB Clinic-Laboratory Continuous Quality Improvement (TB CLICQI) in Nigeria: Lessons learntTuberculosis clinic/laboratory continuous quality improvement (TB CLICQI) was a proof of concept in Nigeria. It was piloted and implemented in Benue State and the outcome fueled the scale-up. This present study documents the impact and lessons learned during the scale-up at selected states and health facilities.
Laura Madukaji

EP32-409-24-Finding additional TB cases through symptom screening for diagnosis in high burden setting: cough of two weeks is not enoughSystematic screening for tuberculosis (TB) in health facility settings and among priority groups remains an important active case finding strategy in high TB burden countries. National TB programmes will benefit through more attention to accurate diagnosis and earlier start of treatment.
Chidubem Ogbudebe

EP32-410-24-Prevalence of Mycobacterium tuberculosis in sputum among adult clinic attendees compared with the surrounding community in rural South Africa: implications for finding the missing millionsThis analysis compares the findings of a tuberculosis prevalence survey, conducted within primary healthcare clinics, to a community-based survey during the same period. Characteristics of enrolled participants, as well as those with a sputum culture positive for Mycobacterium tuberculosis, are compared.
Indira Govender

EP32-411-24-A country tailored package approach to TB case finding: Challenge TB project experience across 23 countriesHierarchy of tuberculosis (TB) case finding interventions, based on yield, from strengthening healthcare facility TB screening (highest) to TB index case contact investigation (least) and the use of a package approach, driven by patient health-seeking behaviour, and pathway to accessing TB diagnosis and care.
Mustapha Gidado

EP32-412-24-Enhancing the performance of newly established TB services sites through the incorporation of structured demand creation activities in Nigeria: findings from a non-randomised intervention studyTuberculosis (TB) prevention is largely ensured by early case identification and treatment in Nigeria among the non-HIV infected populations. Enhancing the performance of newly established TB service sites, through the incorporation of structured demand creation activities, improves case detection and, thus, prevention of TB.
Aminu Babayi

EP32-413-24-Towards achieving UN General Assembly political declaration on HIV and AIDS: commitment on TB case finding among PLHIV, in IndiaThe study assesses the improvement in coverage of intensified case finding among persons living with HIV, in India, as a result of a collaborative, multipronged approach involving capacity building and periodic supervision of the activity.
Deepak Balasubramanian

Loading...
Processing. Please wait.
Loading...