19 October-1 December 2020
The 51st Union World Conference On Lung Health
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Channel 4
SP-32-Regional studies that are improving the zoonotic TB scientific evidence base
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query_builder 12:30 - 13:50 | Event time (GMT+2)
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SP-32-Regional studies that are improving the zoonotic TB scientific evidence base
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The Roadmap for Zoonotic TB highlights the needs and opportunities for improving the scientific evidence base through a 'one health' approach. This includes the systematic assessment of the burden and impact of zoonotic tuberculosis (zTB) in people and the development of strategies for reducing the risk of spillover from livestock. This symposium brings together internationally recognised multidisciplinary experts who successfully planned and implemented zTB programmes in endemic areas, demonstrated how this disease is generally under-reported and who highlighted the challenges and opportunities for assessing zTB burden as well as developing fit for purpose strategies for zTB control and reduction of health impacts.

12:30 - 12:35: Introduction

12:35 - 12:45: A comprehensive one- health approach to combat bovine TB in Santa Catarina state, BrazilBovine tuberculosis (TB) cases in humans often go undetected or misdiagnosed because current laboratory tests cannot differentiate the bacteria that causes bovine TB, leading to death or delayed treatment in patients. Dr Anzai is assessing new diagnostic tests that will reduce cost, enable rapid detection and significantly aid in preventing transmission of bovine TB between animals and from animals to humans.
Eleine Anzai

12:45 - 12:55: Tackling zoonotic TB through animal disease control: the French experienceHer programme at ANSES has demonstrated that a group of second line molecular tests could confidently be added as an official test in order to accelerate the diagnosis process and improve bovine tuberculosis (TB) surveillance in Europe and to render control and eradication programmes more efficient in the future. This programme will also aid in the assessment of bovine TB cases transmitted to humans.
María Laura Boschiroli

12:55 - 13:05: Surveillance of animal-adapted Mycobacterium tuberculosis complex in clinical and bovine carcasses in Ghana: a call for active one-health approach for TB controlThe true burden of zoonotic tuberculosis (zTB) remains unknown, due to lack of specific diagnostics for distinguishing the animal-adapted variants from the human-adapted Mycobacterium tuberculosis complex. Furthermore, due to lack of funding and, to some extent manpower, routine surveillance is not done. My presentation will span from earlier screening activities we conducted with the veterinary services on herds from a tertiary research facility and from free-range as well as findings from the population-based molecular epidemiological study and an on-going study analysing for mycobacteria among carcasses from selected slaughterhouses.
Dorothy Yeboua-Manu

13:05 - 13:15: M. bovis infection in Baja California: a cattle-cheese-human trifectaBaja California in Mexico has a longer border with the US than with other Mexican states and is home to the busiest land border crossing region in the world. There are an estimated 50 million legal human crossings per year, making it a region highly susceptible to the movement of pathogens. This is thought to be one of the main reasons why Baja California is the Mexican state with one of the highest rates of tuberculosis (TB) in humans and food animals in the country. This area should be a model area for generating robust scientific evidence to further advocate for funding and political commitment to address the challenges posed by zoonotic TB.
Alejandro Perera

13:15 - 13:25: Defining genes essential for the survival of Mycobacterium bovis to identify novel therapeutic targets for zoonotic TBLineages of the are highly similar genetically yet show distinct host preferences. Several studies identifying the impact of sequence variation on differences in gene expression have provided useful insights into the differences between Mycobacterium tuberculosis complex lineages. However, studies examining the impact on sequence variation on the genetic requirements for survival have been limited to the human adapted lineages.
We are using TnSEQ in order to identify the genetic requirements for survival of the reference strain of Mycobacterium bovis. We have used the MycomarT7 phagemid system which inserts into permissive TA sites across the genome. Transposon insertions were randomly distributed throughout the genome and 34,178 out of a total of 73,536 TA sites contained insertions. CRISPRi interference has been successfully established in the laboratory and will be utilised to validate putative essential genes.

Sharon Kendall

13:25 - 13:50: Q&A session

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Channel 4
OA-34-Risk factors, surveillance and control strategies in potential zoonotic TB hotspots
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query_builder 11:00 - 12:20 | Event time (GMT+2)
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OA-34-Risk factors, surveillance and control strategies in potential zoonotic TB hotspots
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11:00 - 11:05: Introduction


11:05 - 11:13: OA-34-707-24-Clustering of Moroccan and Spanish Mycobacterium bovis isolates from slaughtered cattle Bovine tuberculosis (TB) is endemic in Morocco, in addition, zoonotic TB risk is high, but the exact burden is unknown. In this study, we investigated a larger set of Mycobacterium bovis genetic profiles to better define the phylogenetic links between Moroccan isolates and those found worldwide.

Hind Yahyaoui Azami

11:13 - 11:21: OA-34-708-24-Spoligotyping-based direct detection and identification of Mycobacterium tuberculosis complex from cattle samples The public health consequences of Bovine tuberculosis (TB) in India have so far been scarcely investigated and often neglected. India is identified as a high burden country for TB by the World Health Organization and the reports of TB infection in cattle is making the situation even more alarming.  

Kannan Palaniayndi

11:21 - 11:29: OA-34-709-24-Prevalence and risk factors of mycobacterial infections among pastoralists and their cattle in southwestern Nigeria Active case finding of the prevalence and associated risk factors of mycobacterial infections among pastoralist communities - a neglected and high-risk group that are unaware of both their health status and that of their cattle herds - was carried out in Ibarapa area, Oyo State, Nigeria.

Olubukola Adelakun

11:29 - 11:37: OA-34-710-24-Facility-based characteristics are strong predictors of poor TB treatment outcomes in children in Pakistan Few studies have examined predictors of poor tuberculosis (TB) treatment outcomes among children without HIV infection. We assess individual demographic and clinical information as well as facility-based characteristics to identify predictors of unsuccessful paediatric treatment outcomes in children treated for drug-susceptible TB in Pakistan.

Meredith Brooks

11:37 - 11:45: OA-34-711-24-Diagnostic utility of microbiological and histopathological testing in the diagnosis of paediatric TB lymphadenitis in Indian children screened for the SHINE trial The diagnosis of tuberculosis (TB) lymphadenitis in children poses a challenge due to a wide range of differential diagnoses. This is a retrospective study of microbiological (AFB smear, Xpert MTB/RIF, LJ and MGIT cultures) and histopathology testing of peripheral lymphnode samples from children aged<16 years, who were screened for the SHINE trial at Indian sites.

SYED HISSAR

11:45 - 11:53: OA-34-712-24-Thirty-year follow-up of a double-blind randomised, placebo-controlled trial of repeat bacillus Calmette–Guérin vaccination in northern Malawi Forty-seven thousand individuals with bacillus Calmette–Guérin (BCG) vaccine scars were randomised from 1986–89 to receive a second BCG vaccination or placebo. We will present efficacy estimates based on 824 individuals, ascertained with tuberculosis through 2018, including analyses by age, tuberculin status, HIV status and M. tuberculosis lineage.

Paul Fine

11:53 - 12:20: Q&A


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