19 October-1 December 2020
The 51st Union World Conference On Lung Health
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Channel 5
OA-08-The Union student late-breaker session on lung health
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query_builder 15:00 - 16:20 | Event time (GMT+2)
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place Online Session/Virtual
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mic English
OA-08-The Union student late-breaker session on lung health
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This session is sponsored by the Research Institute of Tuberculosis, Japan Anti-Tuberculosis Association (RIT/JATA).


15:00 - 15:05: Introduction


15:05 - 15:15: LB-2092-21-Utility of previously identified host immunological biomarkers in the diagnosis of TB and monitoring therapy response in high- and low- endemic countries To assess their potential global relevance, candidate tuberculosis (TB) biomarkers require validation in different geographical settings. We evaluated the utility of selected biomarkers in participants recruited from low- and high-TB endemic regions and identified promising biosignatures. Our data highlights the importance of the use of harmonised designs in multicentered studies.

Bih H. Chendi

15:15 - 15:25: LB-1968-21-Characterisation of clinical subtypes of antiretroviral therapy-associated tuberculous meningitis using host transcriptomic analysis Tuberculosis meningitis (TBM) patients are at high risk of IRIS-related (immune reconstitution inflammatory syndrome) mortality, but there is limited data on unmasking IRIS in TBM. We sequenced CSF RNA to describe the host immune response, alongside clinical characteristics, of Ugandan patients presenting with TBM after initiation of antiretrovirals, to determine features of unmasking IRIS.

Carson M Quinn

15:25 - 15:35: LB-2082-21-Assessment of whole genome sequencing technology applied to drug-resistant TB diagnosis In the last decades, whole genome sequencing has become a promising tool in the diagnosis of drug-resistant tuberculosis, evincing the limitations of the phenotypic drug-susceptibility testing. We have evaluated the reliability of its resistance profile prediction in a local study based on a low burden setting of Spain.

Ana María García Marín

15:35 - 15:45: LB-2115-21-Personalised adherence management in TB: using artificial intelligence to schedule targeted interventions We designed an artificial intelligence-based intervention decision support system for community health workers managing tuberculosis medication adherence. The assistant learns to make intervention recommendations, subject to available resources, based on individual patient responsiveness to interventions over time.

Jackson A. Killian

15:45 - 15:55: LB-2119-21-Tale of the tape: use of mid-upper arm circumference to identify increased probability of paediatric TB treatment failure and mortality in a low-resource setting Mid-upper arm circumference (MUAC) independently identifies paediatric tuberculosis (TB) cases that are more likely to later experience TB treatment failure or mortality. Thus, in resource-limited settings, a simple tape measure may aid clinicians in targeting young children in need of more intensive monitoring and clinical care.

Daniel Van Aartsen

15:55 - 16:05: LB-2047-21-Impact of COVID-19 pandemic on latent and active TB treatment registrations in Montreal, Canada: a retrospective study at the Montreal Chest Institute Since the declaration of a global pandemic in March 2020, COVID-19 has disrupted the delivery of tuberculosis (TB) services worldwide. We assessed the effect of COVID-19 on the number of people registered for latent or active TB treatment in Montreal, the city with the highest COVID-19 burden in Canada.

Mariane Saroufim

16:05 - 16:20: Q&A


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Channel 6
OA-20-The Union late-breaker session on COVID-19
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query_builder 15:00 - 16:20 | Event time (GMT+2)
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place Online Session/Virtual
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OA-20-The Union late-breaker session on COVID-19
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15:00 - 15:05: Introduction


15:05 - 15:13: LB-2100-22-Comparative evaluation of the clinical accuracy of SARS-CoV-2 serological rapid diagnostic tests and manual ELISAs The clinical accuracy of 25 commercially available SARS-CoV-2 antibody tests in five countries - Brazil, Italy, Spain, Switzerland and the USA - was determined. Our results suggest that the majority of antibody rapid diagnostic tests (RDT's) have insufficient sensitivity and specificity, but there are several high performing lab-based ELISAs that meet World Health Organization target product profile targets.

Jilian Sacks

15:13 - 15:21: LB-2093-22-Clinical accuracy, ease of use and limit of detection of SARS-CoV-2 antigen-detection rapid diagnostic tests The clinical performance, limit of detection and ease of use of six commercially available SARS-CoV-2 antigen rapid diagnostic tests was assessed in three countries - Brazil, the UK and Germany. Though there is substantial performance variability, our results suggest that at least two meet a minimum of 70% clinical sensitivity and 97% clinical specificity.

Jilian Sacks

15:21 - 15:29: LB-2090-22-High mortality among persons with comorbid rifampicin-resistant TB and COVID-19 in Khayelitsha, South Africa In April 2020, there were 181 active rifampicin-resistant tuberculosis (RR-TB) patients; 46 (25%) were tested for COVID-19 (n=22[48%] newly diagnosed) and 17 (37%) tested COVID-19 positive. Among those co-infected, eight (47%) died. Few newly diagnosed RR-TB patients were investigated for COVID-19 suggesting missed opportunities to detect COVID-19. Additionally, the mortality was high.

Erika Mohr-Holland

15:29 - 15:37: LB-2122-22-TB and COVID-19 co-infection among people with cough screened during active case finding of COVID-19 in the community with a high prevalence of TB This study shows the experience of screening for both tuberculosis and COVID-19 at the same time, using Xpert MTB/Rif and SARV-CoV-2 PCR tests, in the north of Lima during the programmatic activities on COVID-19 response in Peru.

Marco Tovar

15:37 - 15:45: LB-2113-22-Automated detection of COVID-19 in chest X-rays using deep learning for instant triage in hospital settings and integration with structured report generation Artificial intelligence screening of chest X-rays for COVID-19, integrating with structured reporting tools, can be an excellent tool for hospital triage to streamline workflows and hasten report turnaround time. It can act as a valuable auxiliary method for pre-screening symptomatic suspects and for providing final diagnostic reports with imaging, keeping experts in the loop.

Amit Kharat

15:45 - 15:53: LB-2051-22-Potential impact of the COVID-19 pandemic on essential TB services in Sri Lanka Common respiratory origin and interference with host immunity results in many clinical similarities between tuberculosis (TB) and COVID-19. Due to COVID-19, the Sri Lankan healthcare system is stretched beyond capacity. The catastrophic effect of COVID-19 on normality of the population and healthcare services has a negative impact on TB case detection.

Chathurani Mekala Wickramaarachchi

15:53 - 16:20: Q&A


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Channel 4
OA-30-The HIV-TB and diabetes late-breaker session
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OA-30-The HIV-TB and diabetes late-breaker session
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15:00 - 15:05: Introduction


15:05 - 15:17: LB-1903-23-Diagnostic accuracy of a novel point-of-care urine lipoarabinomannan assay for the detection of TB among adult outpatients in Zambia: a prospective cross-sectional study The SILVAMP FujiLAM assay is a promising, new, rapid point-of-care test for tuberculosis (TB). However, to date, it has not been evaluated using fresh urine specimens. We prospectively determined the diagnostic accuracy of the SILVAMP FujiLAM assay among HIV-positive and HIV-negative outpatients with presumptive TB in Zambia.

Monde Muyoyeta

15:17 - 15:29: LB-1930-23-Glycemic trajectories after TB diagnosis and treatment outcomes of new TB patients: a prospective cohort study in Eastern China Tuberculosis (TB) patients with either transient hyperglycemia or glycemic instability, were multifold higher risk of poor treatment outcomes compared to patients with normal glycemic trajectories. These patients represented half of treatment failures in the cohort. Glycemic kinetics, regardless of diabetes status, may be an important marker for  response to TB treatment.

Leonardo Martinez

15:29 - 15:41: LB-2044-23-Prevalence of diabetes mellitus among patients with TB in low- and middle-income countries: a systematic review of 39 cross-sectional studies Diabetes mellitus (DM) and tuberculosis (TB) are both among the top ten global causes of death and affect low- and middle-income countries (LMIC). The objective of this paper is to assess the prevalence of DM among patients with TB in LMIC and the percentage of those newly diagnosed with DM.

Jessica Lewis

15:41 - 15:53: LB-2071-23-Exploring barriers and facilitators of diabetes mellitus management within the Philippines TB programme: a mixed methods patient-centred health systems study This study aims to understand barriers and facilitators to diabetes mellitus (DM) service delivery within tuberculosis (TB) DOTS clinics that impact on patient-level DM management, using a quantitatively driven mixed methods approach within a cohort of more than 800 patients undergoing TB treatment in the Philippines.

Lauren Oliveira Hashiguchi

15:53 - 16:20: Q&A


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Channel 1
OA-39-The Union/CDC late-breaker session on TB
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OA-39-The Union/CDC late-breaker session on TB
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15:00 - 15:05: Introduction


15:05 - 15:13: LB-2112-24-Diagnostic accuracy, clinical impact and antimicrobial resistance consequences of using trial-of-antibiotics for TB diagnosis: a randomised controlled trial in Malawi (ACT-TB study) Antibiotics, commonly used during tuberculosis (TB) diagnosis, have unknown diagnostic accuracy and effectiveness. This three-arm randomised trial in Malawi (azithromycin versus amoxycillin versus standard of care) showed modest, increased specificity with immediate antibiotics, but no other clinical benefit on missed TB diagnosis, hospitalisation or death. Trial-of-antibiotics, therefore, offers only limited benefit.

Titus Divala

15:13 - 15:21: LB-2087-24-Xpert performance evaluation for linkage to TB care (XPEL TB): a cluster randomised trial An ultra-pragmatic cluster randomised trial was conducted to evaluate the effectiveness of a streamlined tuberculosis (TB) diagnostic strategy, centred around onsite Xpert testing at 20 health centres in Uganda. This intervention increased 14-day TB treatment initiation by 56% and improved quality metrics along the entire TB diagnostic evaluation cascade of care.

Achilles Katamba

15:21 - 15:29: LB-2110-24-Comparable diagnostic performance of the T-SPOT TB test, using manual density gradient cell isolation, versus automated positive selection with the T-Cell TM Kit This prospective study aimed to compare the T-SPOT tuberculosis (TB) test, using peripheral blood mononuclear cells (PBMCs) isolated via manual density gradient separation (reference) performed between 0-8 hours after blood collection, versus automated positive selection with magnetic bead isolation with the T-Cell TM Kit performed between 0-55 hours post collection.

Shu-Hua Wang

15:29 - 15:37: LB-2070-24-Deep learning algorithm classifies active TB from normal - and other abnormal - chest X-rays with high accuracy on large scale dataset An artificial intelligence algorithm, trained and tested on a large scale dataset, can classify active tuberculosis (TB) from normal - and other abnormal - chest X-rays with high accuracy. It can be applied in TB screening programmes where a large amount of population are evaluated in a short period of time with limited radiologists.

Yuan Li

15:37 - 15:45: LB-2127-24-Tool to assess willingness to prescribe TB preventative therapy among healthcare workers in rural South Africa A tool to assess healthcare worker willingness to prescribe tuberculosis preventative therapy (TPT), in rural South Africa, was derived using exploratory factor and regression analyses. Such a tool is relevant as TPT initiation rates have decreased among people living with HIV despite South Africa's initial successful TPT roll out.

Amiya Ahmed

15:45 - 15:53: LB-2056-24-Shorter treatment for minimal TB in children: main findings from the SHINE trial SHINE was an open-label treatment shortening trial in children with minimal (non-severe and smear-negative), symptomatic drug-susceptible tuberculosis (TB). One thousand, two hundred and four children in Africa and India were randomised to four-month versus six-month treatment, using World Health Organization-recommended paediatric fixed-dose formulations, and followed for 18 months. Here we will be presenting the main trial results.

Eric Wobudeya

15:53 - 16:01: LB-2046-24-Temporal non-adherence and TB treatment outcomes? ‘O art of subtlety and secrecy!’ When adherence to anti-tuberculosis medication is considered, adherence levels are frequently reduced to binary categorisations (above 80/90% is ‘good’), ignoring their temporal subtleties and the intricacies of the adherence-outcome relationship. We sought to determine this relationship in detail, including the dynamics of adherence between the initiation and continuation phases.

Helen R. Stagg

16:01 - 16:20: Q&A


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