Sessions

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Organised by: QIAGEN
Global health experts are working to slow the COVID-19 pandemic – but responding to COVID-19 has also forced disruption of existing TB control programs around the globe. QIAGEN is committed to fighting COVID-19 and TB, developing innovative new testing solutions so that no one is left behind in the battle against pandemic lung diseases. Join our interactive symposium as we discuss QIAGEN's evolving solutions in two parts:
Part 1. QIAreach QuantiFERON-TB: A simple and accurate solution for decentralized TB infection screening
Currently in development, the QIAreach QuantiFERON-TB is a field-friendly, portable latent TB testing solution that will expand access to TB testing where it's needed the most. QIAGEN's assay development team will introduce the test and provide a scientific review of early performance data. This will be followed by first-hand experiences from ongoing trials of the test conducted in Zambia.

Part 2. Tackling TB and COVID-19 together: From centralized to decentralized testing
Stop TB and the WHO have highlighted the overlapping symptoms and risk groups shared by COVID-19 and TB. QIAGEN's Dr. Masae Kawamura will discuss shared disease etymologies and introduce QIAGEN's portfolio of cutting-edge solutions for both centralized and decentralized testing. Centralized solutions include: QuantiFERON-TB Gold Plus (TB) and QIAstat-Dx Respiratory SARS-CoV-2 Panel (SARS-CoV-2). Decentralized solutions include: QIAreach QuantiFERON-TB (TB), QIAreach Anti-SARS-CoV-2 Total (not available in all markets) and QIAreach SARS-CoV-2 Antigen Test (SARS-CoV-2).
Products and product claims may differ from country to country based on regulations and approvals. Contact your country representative for further details.
QIAreach QuantiFERON-TB and QIAreach SARS-CoV-2 Antigen are currently under development and coming soon. QIAreach QuantiFERON-TB is intended for high-TB-burden countries.

09:45 - 09:50: Introduction


09:50 - 09:57: QIAreach QuantiFERON-TB: a simple and accurate solution for decentralised TB infection screening Currently in development, the QIAreach QuantiFERON-TB is a field-friendly, portable latent tuberculosis (TB) testing solution that will expand access to TB testing where it's needed the most. QIAGEN's assay development team will introduce the test and provide a scientific review of early performance data. This will be followed by first-hand experiences from ongoing trials of the test conducted in Zambia.

Kwame Shanaube

09:57 - 10:11: Tackling TB and COVID-19 together: from centralised to decentralised testing Stop TB and the World Health Organization have highlighted the overlapping symptoms and risk groups shared by COVID-19 and tuberculosis (TB). QIAGEN's Dr. Masae Kawamura will discuss shared disease etymologies and introduce QIAGEN's portfolio of cutting-edge solutions for both centralised and decentralised testing. Centralised solutions include: QuantiFERON-TB Gold Plus (TB) and QIAstat-Dx Respiratory SARS-CoV-2 Panel (SARS-CoV-2). Decentralised solutions include: QIAreach QuantiFERON-TB (TB), QIAreach Anti-SARS-CoV-2 Total (not available in all markets) and QIAreach SARS-CoV-2 Antigen Test (SARS-CoV-2).

Masae Kawamura

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Organised by: Uppsala University and Carlos III University
The Innovative Medicines Initiative (IMI) Antimicrobial Resistance (AMR) Accelerator is a recently formed consortium of over 50 partners, unified by a common goal of developing new tools and therapeutics to fight resistant pathogens, with a particular focus on targeting tuberculosis (TB) and Gram-negative bacteria.   The initiative is comprised of three core pillars: COMBINE, a capability building network; ERA4TB, a TB drug development  network; and portfolio building networks that include the projects TRIC-TB and RespiriTB. The scope of the AMR Accelerator is broad;  aiming to consolidate expertise under one structure to tackle AMR and accelerate the progression of antibiotics towards the clinic.

09:45 - 09:55: Innovative Medicines Initiative Antimicrobial Resistance Accelerator: structure and strategy Presentation of the consortium supporting all the projects in the Antimicrobial Resistance Accelerator: COMBINE

Karen O´Dwyer

09:55 - 10:10: The European Regimen Accelerator for Tuberculosis (ERA4TB): concept, vision and progress Presentation of the consortium looking at progressing antitubercular drugs within the Antimicrobial Resistance Accelerator: ERA4TB

Stewart Cole

10:10 - 10:20: Innovative Medicines Initiative Antimicrobial Resistance Accelerator: a new public-private partnership to tackle the antimicrobial resistance issue worldwide: Tric TB Presentation of Tric TB: portfolio building networks of the Antimicrobial Resistance Accelerator.

Michel Pieren

10:20 - 10:30: New approaches to targeting the respiratory chain of M. tuberculosis Presentation of RespiriTB: portfolio building network of the Antimicrobial Resistance Accelerator.

Meindert Lamers

10:30 - 10:45: Q&A session

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Organised by: Johnson & Johnson Global Public Health

Confirming the diagnosis of tuberculosis (TB) is a major challenge, especially in very young children. For drug-resistant TB, this means that children may end up on suboptimal therapy or even on no therapy at all.
Researchers around the world have explored how to improve the diagnosis of TB in children. In this satellite session, we plan to facilitate the sharing of learnings from paediatric TB experts on how healthcare providers and  national TB programmes can improve the identification of children with TB so that they receive appropriate care.

09:45 - 10:00: Epidemiology of childhood TB and drug-resistant TB Prof Seddon will describe the current epidemiology of childhood tuberculosis

James Seddon

10:00 - 10:15: Symptom-based approach to diagnosing childhood TB. What next? Variable presentations of tuberculosis (TB) among children present a unique challenge. In many instances, objective diagnostic  modalities (eg sputum culture or molecular methods) are suboptimal so physicians have to rely on 'clinical' judgement,  supplemented by epidemiological information, to make a diagnosis. Canwe do better?

Ben Marais

10:15 - 10:30: Research agenda to improve TB treatment outcomes in children The world has made some progress in the treatment of drug-resistant tuberculosis (DR-TB) disease. It is imperative that children not be  just a footnote to this progress, but that they are included in efforts to find more effective and better tolerated drug regimen for DR-TB. 
Prof Hesseling will discuss current gaps in the treatment of childhood DR-TB, some of the ongoing research activities to address these gaps  and the way forward to ensure that children benefit from advances in the treatment of DR-TB.

Anneke Hesseling

10:30 - 10:45: Challenges in diagnosing and treating TB in children Children have been neglected in the fight against tuberculosis (TB). Despite being the number one infectious disease killer, TB does  not feature on the child survival agendas. There is need to elevate childhood TB to the top of the agenda and we do what  needs to be done to ensure that no child unnecessarily dies from TB, if we truly intend to eliminate TB.

Farhana Amanullah

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All TBScience 2020 E-posters will be displayed from 10 am Central European Summer Time (CEST), on Wednesday, 21 October for the duration of the conference and beyond

EP-TBS-01-Increased neutrophil count and decreased neutrophil CD15 expression correlate with TB disease severity and treatment response
Lerato Ndlovu

EP-TBS-02-Genome-wide identification of Mycobacterium tuberculosis genetic markers associated with the history of BCG vaccination
Kamela Charmaine S. Ng

EP-TBS-03-Characterization of regulatory B-cells for tuberculosis management
Irene Latorre

EP-TBS-04-Different antimycobacterial activity of alveolar macrophages in various lung legions of tuberculosis patients
Sergey Skornyakov

EP-TBS-05-Plasma mediators of phagocytosis in tuberculosis patients during anti-TB treatment and zinc supplementation
Victory Edem

EP-TBS-06-Discerning divergent tuberculosis endotypes: A meta-analysis of individual patient data
Andrew DiNardo

EP-TBS-07-Plasma Interferon (IFN)-g Inducible Protein 10 (IP-10) levels but not the QuantiFERON Gold plus assay correlate with disease severity and paradoxical reactions in extrapulmonary tuberculosis
Isabelle Suarez

EP-TBS-08-Host immune factors related to non-multidrug resistant tuberculosis with treatment history in Vietnam
Naoto Keicho

EP-TBS-09-Risk factors for the development of tuberculosis in children with chronic non-specific lung diseases.
Sofya Nakonechnaya

EP-TBS-10-Polyfunctional T-cells and IL-2 production decrease during pregnancy in women with latent TB infection
Jyoti Mathad

EP-TBS-11-Neutrophils Contribute to Tuberculosis-linked Inflammation and lung pathology
Caleb Nwongbouwoh Muefong

EP-TBS-12-Association of neutrophil-derived inflammatory mediator levels with lung pathology in active tuberculosis at diagnosis
Caleb Nwongbouwoh Muefong

EP-TBS-13-Characterising the BCG-induced antibody response for antigen discovery
Rachel Tanner

EP-TBS-14-ESAT-6 / CFP-10-stimulated metabolic activity of pleural fluid cells if cured tuberculosis or TB / HIV
Sergey Skornyakov

EP-TBS-15-Blood-Based Biomarkers of Tuberculosis in Children Integrating Metabolomic and Transcriptomic Data
Jeffrey A Tornheim

EP-TBS-16-Identification of TGF-β1 in pleural tuberculosis: the possible role in fibrosis
Silvio Renan Pinheiro Victor de Araújo

EP-TBS-17-Analysis of serum microRNAs as pulmonary tuberculosis biomarkers
JaeIn Jung

EP-TBS-18-Up-regulated programmed death protein 1 expression on CD4 T cells in patients with MDR-TB  associated with lung lesion and mycobacterial load
Qi Tan

EP-TBS-19-Malnutrition affects levels of vascular endothelial growth factor levels among children and adolescents with pulmonary tuberculosis?
Caio Pluvier Duarte Costa

EP-TBS-20-Towards identification of protein markers of Mycobacterium tuberculosis H37Rv extracellular vesicles (EV)
MEHALENE JAYARAM

EP-TBS-21-Increased frequency of CD39+ regulatory T cells in the pleural fluid of patients with Tuberculosisin comparison to other exudative causes
Ana Paula Santos

EP-TBS-22-Longitudinal analysis of M. tuberculosis-specific T cell responses demonstrates dynamic T cell responses to ESAT-6 and CFP-10 during pregnancy independently of mitogen responses.
Aparajita Saha

EP-TBS-23-Serum Cytokine Profile as Biomarker for Multi-drug Resistant Tuberculosis
Alahaman Nana Boakye

EP-TBS-24-Reanalysis and validation of Tuberculosis genes signature in blood and pleural fluid from patients with exudative pleural effusion
Raquel da Silva Corrêa

EP-TBS-25-TimBre, Cough based screening of Pulmonary Tuberculosis using Machine Learning that is Explainable and Interpretable
Rahul Pathri

EP-TBS-26-HbA1C as prognostic factor in PTB
Sarang Patil

EP-TBS-27-Better intradermal delivery for bacille Calmette-Guérin (BCG) vaccine by microneedles in healthy adults of S. Korea
Hyejon Lee

EP-TBS-28-MULTIPLEX BIOMARKER ASSAY FOR DETECTION OF MYCOBACTERIUM TUBERCULOSIS
Puneet Gupta

EP-TBS-29-Role of the chemokine receptor CXCR3 in the recruitment and retention of lung resident memory T cells following a pulmonary TB vaccine. 
Warwick Britton

EP-TBS-31-Benefit of Quantiferon-TB Gold plus in incidence of TB disease in Heath care workers of Central Chest Institute of Thailand
piamlarp sangsayunh

EP-TBS-32-The blood monocyte/lymphocyte, neutrophil/lymphocyte and platelet/lymphocyte ratios in children with pulmonary tuberculosis
Larissa Gorbach

EP-TBS-33-Pulmonary tuberculosis patients have an anaerobe-enriched microbiota associated with a pro-inflammatory peripheral host immune phenotype
Charissa Naidoo

EP-TBS-34-The epidemiologic impact and cost-effectiveness of new tuberculosis vaccines on rifampicin resistant and multidrug resistant tuberculosis in India and China
Chathika Weerasuriya

EP-TBS-36-Novel, culture-free, same-day TB diagnosis with ultrasensitive ELISA
Rikiya Takeuchi

EP-TBS-37-Tuberculosis screening in point-of-care settings: Proof-of-concept for a fast and easy sample-to-answer qPCR-based protocol
Alexandre Dias Tavares Costa

EP-TBS-38-Diagnostic accuracy of three urine lipoarabinomannan tuberculosis assays in HIV-negative outpatients
Tobias Broger

EP-TBS-39-To Study The Presence Of Live Mycobacterium Tuberculosis In Resected Lung Specimens Of Patients Undergoing Lung resection Surgery For Post-Tuberculosis Sequelae
Pallavi Purwar

EP-TBS-40-What can tuberculosis prevalence surveys tell us about the duration of asymptomatic bacteriologically-positive disease?
Chu-Chang Ku

EP-TBS-41-An RNA signature for tuberculosis risk in pregnant women: a prospective cohort study from India
Jyoti Mathad

EP-TBS-42-Analysis of mycobacterial trans-renal DNA for the diagnosis of Tuberculous Meningitis in adults.
Manisha Dass

EP-TBS-43-Developing a tool to identify and screen Latent Tuberculosis Infection (LTBI) with likelihood of progression to active Tuberculosis (ATB)
Prashant Singh

EP-TBS-44-QuantiFERON TB plus-negative results in clinically diagnosed paediatric tuberculosis: immune suppression or misdiagnosis?
Gloria Ivy Mensah

EP-TBS-45-Evaluation of a blood-based antigen test for tuberculosis in HIV-exposed children younger than 5 years
Tony Hu

EP-TBS-46-Adverse drug reactions in MDR TB Patients on ATT
Sarang Patil

EP-TBS-47-Species and Drug Susceptibility profile of Non-tuberculous Mycobacteria isolated from presumptive TB cases
PRIYA RAJENDRAN

EP-TBS-48-MAMA-PCR assay for the detection of point mutations associated with drug resistance in Mycobacterium tuberculosis clinical isolates
Raquel Muñiz-Salazar

EP-TBS-49-Genomic diversity in Mycobacterium tuberculosis from human lung resections reveals a high degree of multiclonal infections in a high-burden MDR-TB setting
Miguel Moreno-Molina

EP-TBS-50-Pathogen genome sequencing to guide treatment regimen designs for multidrug-resistant tuberculosis
Hans-Peter Grobbel

EP-TBS-51-An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosis
Victoria Furió

EP-TBS-52-Antibiotic Resistance Profile Determination Using Whole Genome Sequencing
Ryan Howard

EP-TBS-53-Rapid genomic drug resistance prediction from clinical Mycobacterium tuberculosis specimens using amplicon based deep sequencing based on Deeplex-MycTB
Stefan Niemann

EP-TBS-54-Multi-resistant tuberculosis and HIV infection in Kinshasa: 2011-2018. DRC “Epidemiological, clinical and therapeutic aspects”
Nicole ANSHAMBI

EP-TBS-55-Long Read DNA Sequencing of XDR/MDR Tuberculosis Samples to Investigate Factors Leading to Resistance and Virulence
Michael Harris

EP-TBS-56-Genome-wide detection of epistasis in antibiotic resistant M. tuberculosis
Anna Green

EP-TBS-57-Population structure, biogeography and transmissibility of Mycobacterium tuberculosis
Luca Freschi

EP-TBS-58-Safety and Efficacy of an MDR-TB All-oral Short-course Regimen in China: An Preliminary Analysis of the MDR-Chi clinical trial
Liang Fu

EP-TBS-59-Drug exposure and minimum inhibitory concentration predict pulmonary tuberculosis treatment response
Xubin Zheng

EP-TBS-60-A novel therapeutic vaccine against multi-drug resistant tuberculosis by T cell-immunity in phase 1 clinical trial.
Masaji Okada

EP-TBS-61-Improving the safety of TB therapy with novel diagnostic biomarkers of liver toxicity – a study in UK and Ugandan patients
Derek Sloan

EP-TBS-62-Tuberculosis meningitis mouse model
Tuhina Gupta

EP-TBS-63-Pharmacokinetics of the three-drug fixed-dose dispersible tablet in children
Aziza Pakhlavonova

EP-TBS-64-Does BCG Vaccination protect against infection with Mycobacterium tuberculosis in Vietnamese schoolchildren?
Puck Pelzer

EP-TBS-65-Time to positivity as a surrogate biomarker of time to culture conversion
Belén P. Solans

EP-TBS-66-Use of the contact management register to identify those with Active and Latent TB, Kenya, Jan-March 2020
RHODA POLA

EP-TBS-67-Predicting Efficacy Outcome of Nine Tuberculosis Drugs in Phase 2a First-in-patients Studies
Nan Zhang

EP-TBS-69-Predicting optimal treatment durations for tuberculosis patients: a risk stratification algorithm and clinical simulation tool
Marjorie Imperial

EP-TBS-70-Adverse Drug Reactions in MDR TB Patients on Category IV Regimen in Western Odisha
SUMAN KUMAR JAGATY

EP-TBS-71-The effect of antiretroviral therapy and preventive tuberculosis therapy with anti-TB drugs on the duration of TB remission in HIV-infected patients
Igor Medvinskiy

EP-TBS-72-A Urine Colorimetric Assay for Levofloxacin Concentrations and Optimized Regimen Development
Prakruti Rao

EP-TBS-73-Development and Application of an Integrated Biomarker - Clinical Endpoint Tool for Late Stage TB Regimen Development and Clinical Trial Design
Marjorie Imperial

EP-TBS-74-Leveraging Neural Networks and Imaging Experts in Loops for Automated Tuberculosis Screening Using Chest Radiographs in Population Screening Programs to ensure efficient workflows.
Amit Kharat

EP-TBS-75-A model for the integration of traditional medicine into conventional medicine for the treatment of Tuberculosis (TB) in Zimbabwe
Winnet Enerita Chipato

EP-TBS-76-Point-of-Care Saliva Assay for Levofloxacin Concentrations and Personalized Dosing in Patients with Multidrug-Resistant Tuberculosis in Tanzania
Sagal Mohamed

EP-TBS-77-PBPK Model Informed Prediction to Evaluate the Effect of Renal Impairment and OCT genotypes on the Ethambutol Disposition
Yumi Park

EP-TBS-78-Development of Population Pharmacokinetic Model of the First-line anti-TB drugs in Korean patients with TB for Therapeutic Drug Monitoring Guided Dose Adjustment
Yumi Park

EP-TBS-79-Model Informed Personalized Dosing Algorithm Development for TB Therapy in Center for Personalized Precision Medicine (cPMTb)
Yumi Park

EP-TBS-80-Classifying adherence trajectories: an innovative tool for​ regimen development
Stephanie Law

EP-TBS-81-Predicting pretomanid penetration into patient lesions of tuberculosis
Jacqueline Ernest

EP-TBS-82-Rifapentine pharmacokinetics and pharmacodynamics: murine and human models to identify optimal dosing for treatment of latent M. tuberculosis infection
Jacqueline Ernest

EP-TBS-83-SLCO1B1 and SLC10A1 polymorphism and plasma rifampin concentrations in patients with co-morbidity tuberculosis-diabetes mellitus in Baja California, Mexico
Ricardo Perea-Jacobo

EP-TBS-84-Individual-Level Data Meta-Analysis of Adverse Events from Clinical Trials of Drug Sensitive Tuberculosis Treatment Regimens
Leah Jarlsberg

EP-TBS-85-G-clamp-inspired ligands and their effects on G-quadruplexes from Mycobacterium tuberculosis
Egor Shitikov

EP-TBS-86-Prediction of early bacterial activity (EBA) of bedaquiline in tuberculosis
Federico Romano

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All E-posters are accessible via the "E-posters" section of the conference platform until 30 November.

EP14-230-22-Is TB contact investigation feasible in resource-limited settings like Malawi?Tuberculosis contact investigation (TB-CI) can assist TB programmes in early detection of TB among household and close contacts. Malawi TB programme developed SoPs for TB-CI, trained frontline healthcare workers and instituted mentoring and support supervision on TB-CI. We, therefore, analysed implementation of TB-CI in Malawi from 2016 to 2019.
Henry Kanyerere

EP14-231-22-Targeted active TB case finding using mobile TB diagnostic units among key affected populations in Malawi: an innovative approach to reach the missing TB casesThis abstract demonstrates a positive impact on Malawi's innovative active tuberculosis (TB) screening intervention by using Mobile Diagnostic Units (MDU's) in high-risk, urban populations of Malawi. Lessons learned consider it as a game changer and it can be scaled-up globally to narrow the existing gap in finding the missing TB cases.  
Madalitso M'manga

EP14-232-22-Biomedical support to people affected by TB in prisons: a pilot experience in Cochabamba, BoliviaWe report on a biomedical approach in prisons for improving detection and treatment outcomes of people affected by tuberculosis (TB), which included peer support, sensitisation, diabetes screening, nutritional supplements, monthly peer support meetings and a tracking system for released inmates. This approach yields an increased number of TB confirmed and cured, compared with a period before.  
Rebeca Ledezma Almendras

EP14-233-22-Barriers to TB care among women in selected hard-to-reach areas in Southern Nigeria: a mixed method studyThis study sought to identify barriers to accessing tuberculosis (TB) services among women in hard-to-reach riverine communities in Southern Nigeria. Our findings highlight the need for more robust, gender-sensitive measures to end TB in resource-constrained settings.
Chuka Agunwa

EP14-234-22-Socioeconomic indicators predict neighborhood-level active case finding yields better than historic case notification rates in Lima, PeruWe assessed the utility of targeting (tuberculosis) TB active case finding efforts, based on areas with prior high TB case notification rates, by comparing historic case notifications with screening yields from a community-based active case finding programme using x-ray vans in Lima, Peru.
Meredith Brooks

EP14-235-22-Detection of persons with TB through innovative engagement of standalone private radiology diagnostic centres in Kaduna state, Nigeria, in 2019With low treatment coverage of 22% in Kaduna state, Nigeria, a sizeable number of people with tuberculosis (TB) are missed while patronising standalone private diagnostic centres. Tracking persons with a chest X-ray report suggestive of TB from these sites, in addition to those in the hospital-based settings, will improve TB detection. 
Dauda Samuel Hananiya

EP14-236-22-Finding the missing cases among high risk populations: Lessons from MalawiThis programme evaluation provides the effort of implementing a targeted screening of TB among high risk populations in the identification of TB missing cases in low resource settings. The implementation provides  an analysis of the cascade of TB care among high risk groups using mobile diagnostic units.
Kruger Kaswaswa

EP14-237-22-Improving access to TB services for vulnerable populations: an employer-led model demonstration in IndiaEmployers are a viable entry point to supporting populations vulnerable to tuberculosis (TB). The Employer Led Model (ELM) brought together district administration, district TB programmes and employers to demonstrate a partnership model aimed at improving awareness of TB and to increase access to services by integrating TB within the existing structure of establishments.
Anupama Srinivasan

EP14-238-22-Can mentorship and training improve the implementation of TB infection prevention and control in low-resource settings? Malawi experienceThis abstract is about an improved trend on tuberculosis (TB) infection prevention and control (IPC) indicators following the on-site mentorship and training intervention employed by Malawi National TB Control Programme (NTP). NTP-Malawi revised its TB IPC guidelines to adopt the World Health Organization guidelines in 2015. The programme reviewed the performance trend from 2015 to 2019.
Lameck Mlauzi

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All E-posters are accessible via the "E-posters" section of the conference platform until 30 November.

EP17-263-22-Overcoming challenges of sample transportation for TB testing during COVID-19 lock down, March-April 2020: an interventional study in Telangana, IndiaThe diagnostic services in tuberculosis (TB) were hampered during the COVID-19 lock down. This in turn will reduced early detection of drug-resistant TB. By utilising the available resources, such as the 104 ambulance vans at district level, the challenge of sample transportation and, thus diagnosis, of drug-resistant TB has been addressed.
sumalata Chittiboyina

EP17-264-22-TB patients through telecommunication in COVID-19 situation: BRAC experienceEvery day around 600 COVID-19 cases are diagnosed, which may increase if sample testing capacity can increase. The world is fighting to end infectious diseases. Planned and effective utilisation of resources can ensure uninterrupted tuberculosis (TB) service. However, to increase TB cases finding in a lock down situation is very challenging.
Md Abul Khair Basher

EP17-265-22-Physically distant but still in contact: telephonic counselling for rifampicin-resistant TB patients in South Africa during the COVID-19 pandemicCOVID-19 threatens to undermine progress in the global tuberculosis (TB) response by disrupting routine TB services. Here, we describe telephonic counselling offered to rifampicin-resistant TB (RR-TB) patients in South Africa during the COVID-19 pandemic. Some early benefits include support to address patients’ adherence problems and reduced patient costs in seeking RR-TB care.
Erika Mohr-Holland

EP17-266-22-Programmatic adaptations to the treatment of rifampicin-resistant TB infection in children and adolescents during COVID-19Post-exposure management services were modified in view of COVID-19. The strategy for recalling asymptomatic contacts was revised. Contacts identified as high risk were screened and initiated on treatment during a home visit or at a facility with infection control practices. Multi-month medication refills were provided; follow-up was conducted telephonically.
Erika Mohr-Holland

EP17-267-22-Collaboration in TB and COVID-19 control in Bungoma CountyThe World Health Organization (WHO) declared novel COVID-19 as a global pandemic. COVID-19 has several health system challenges which directly or indirectly affect tuberculosis (TB) services. Complementary COVID-19 and TB response is critical during this pandemic. Both diseases can utilise the capacity building efforts, surveillance and monitoring systems put in place.
Paul Lodi

EP17-268-22-Connecting the DOTS during the COVID-19 pandemic: using community structures and the private sector to establish linkages for increased TB case detection in NigeriaTo optimise social and behaviour change (SBC) efforts amidst COVID-19 restrictions and to sustain tuberculosis (TB) case identification and service delivery in the private sector, SHOPS Plus Nigeria (Sustaining Health Outcomes through the Private Sector) adjusted its SBC strategy to a community-led approach, comprised of patent and proprietary medicine vendors, community structures (mosques and churches) and private clinics.
Ayodele Iroko

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All E-posters are accessible via the "E-posters" section of the conference platform until 30 November.

EP12-208-22-Comparison of neurocognitive assessment in children with TB Meningitis and healthy controls in Pune, IndiaTuberculosis meningitis (TBM) in children affects the brain adversely and results into neurological deficit. The study used The Mullen Scales of Early Learning (MSEL), a well-established measure, to assess neurocognitive impairment among children with TBM before treatment initiation and compared with age-sex matched, healthy controls in India.
Smita Nimkar

EP12-209-22-Effect of community-based interventions on childhood TB treatment outcomes in hard-to-reach areas of Southern NigeriaTreatment Success Rate (TSR) is an important World Health Organziation treatment outcome indicator that measures the quality of tuberculosis (TB) services. We report the effect of a community-based intervention on childhood TB treatment outcomes in hard-to-reach areas of Southern Nigeria.
Okechukwu Ezeakile

EP12-210-22-Fine needle aspiration biopsy of peripheral lymph nodes in children in a high TB incidence setting: practical experience in a referral hospitalPeripheral lymphadenopathy is common in children. We identified all children (<13 years) over a two-year period who had fine needle aspiration biopsy (FNAB) done at Tygerberg Hospital, Cape Town, and determined how well FNAB performed in routine practice in a high TB burden setting and whether children were appropriately managed.
H. Simon Schaaf

EP12-211-22-The adverse effects of prolonged home isolation on adolescents with TB in Lima, Peru: a qualitative studyPeru’s Ministry of Health mandates two months of home isolation for patients with tuberculosis (TB), despite data showing the majority become non-infectious in less time. Prolonged home isolation may negatively impact adolescents’ development. Peruvian study workers interviewed 34 adolescents with pulmonary TB and 15 health providers working in TB care.
Victoria Oliva Rapoport

EP12-212-22-Feasibility of testing paediatric samples for TB diagnosis: implications of the pre-analytical phase, lessons learned and challengesPaediatric tuberculosis (TB) remains a significant cause of death globally, mainly due to difficulties in diagnosis.  Laboratory confirmation is only obtained in a minority of cases due to the difficulty in obtaining samples. The main objective of this analysis was to evaluate the feasibility of a multisample, paediatric TB diagnostic approach.
Neide Gomes

EP12-213-22-A systematic review of the diagnostic accuracy of Xpert MTB/RIF and Xpert Ultra for the diagnosis of TB Meningitis and lymph node TB in childrenWe will discuss the results of a systematic review on the diagnostic accuracy of Xpert MTB/RIF for the diagnosis of Tuberculous Meningitis and lymph node tuberculosis (TB) in children with signs and symptoms of TB.
Alexander Kay

EP12-214-22-Paediatric TB care cascade: an assessment of knowledge, attitude and practice among healthcare providers in Pune district, IndiaThe dependency on sputum for diagnosis and the difficulty of getting it from younger children is the key challenge in the diagnosis of paediatric tuberculosis. Household contact screening and isoniazid preventive therapy are not being implemented effectively due to lack of awareness on the part of healthcare providers, especially in the private sector.
Jitesh Kuwatada

EP12-215-22-Knowledge, attitudes and practices around childhood TB among healthcare workers in sub-Saharan Africa and South-East AsiaWe share the results of a Knowledge-Attitudes-Practices (KAP) survey conducted among healthcare workers (HCWs) at district level in five resource-limited countries. Our findings show great variability in awareness and experience of childhood tuberculosis (TB) case management and highlights potential barriers and facilitators to the decentralisation of childhood TB diagnosis.
Basant Joshi

EP12-216-22-Improving child TB notification through innovative case finding approaches in hard-to-reach areas of Delta State, NigeriaDespite the high prevalence of tuberculosis (TB) in Delta State, Nigeria, the child TB proportion of all TB cases has remained low. A multipronged intervention was implemented in quarter three of 2018 to address the persistent barriers. Implementing a similar strategy nationwide in Nigeria could have a major public health impact.
Ufuoma Aduh

EP12-217-22-Progress towards updated policy guidance for World Health Organization- recommended best practices in paediatric TB/RR-TB careResults from the #StepUpforTB 2020 study show promising adoption of World Health Organization policy guidance for optimal paediatric tuberculosis (TB)/rifampicin-resistant TB (RR-TB) and latent TB infection management.  Evaluating implementation of national paediatric TB/RR-TB guidelines in routine clinical care is the next step to ensuring children and adolescents benefit from best practices.
Pilar Ustero

EP12-218-22-Reasons and routes of admission among hospitalised children and adolescents with rifampicin-resistant TB receiving treatment in South Africa’s ‘injectable-free era’Children and adolescents with rifampicin-resistant tuberculosis (RR-TB) are often hospitalised during treatment. A South African policy released in September 2018 recommended injectable-free treatment for everyone with RR-TB. We describe reasons for hospital admission among individuals <16 years of age admitted for RR-TB treatment in the injectable-free era.
Juli Switala

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EP19-278-22-Mathematical modelling of new TB diagnostics at subnational sites: evaluating the effects on health systems and patients across sites in same province with differing characteristicsDifferent tuberculosis (TB) diagnostic strategies provide different benefits and require different resources.  We collected detailed pathway data from eight sites in a single Philippine province and evaluated five diagnostic strategies at each. Strategies were evaluated from a societal and health system perspective, with factors which significantly influenced the optimum strategies identified.  
Ewan Tomeny

EP19-279-22-Social media as a tool to build capacity and efficient clinical decision making for doctors working in resource-limited settingThe clinical care of presumptive tuberculosis (TB) patients in remote areas can improve significantly by providing distance learning and effectively using social media as a tool to improve knowledge and capacity. This should be practiced in other hard-to-reach areas to provide quality care and accessible health services.
Myat Kay Khine

EP19-280-22-Access to quality TB diagnostic services in Nigeria: the role of specimen transport systemsSince 2016, the National Tuberculosis and Leprosy Control Programme (NTBLCP) adopted and implemented the policy of using GeneXpert machine as the primary TB diagnostic tool. Adoption and strengthening a mixed model for effective sputum specimen transportation system greatly increased access to quality diagnostic services, contributing to improved TB case finding.
Sani Useni

EP19-281-22-Lateral flow lipoarabinomannan test for diagnosis of TB among people living with HIV in selected health facilities in Nigeria: hype or hope?To increase tuberculosis (TB) case detection among people living with HIV (PLHIV), we evaluated the effectiveness of the lateral flow lipoarabinomannan (LF-LAM) test for TB diagnosis in PLHIV across selected states in Nigeria. Being a urine-based point-of-care- test, LF- LAM was found to bridge the diagnostic gap for PLHIV who could not produce quality sputum.
Nkiru Nwokoye

EP19-282-22-Impact of the rapid molecular test on the incidence of TB in an endemic city in the interior of São Paulo, BrazilEcological study. The Prais-Winsten autoregression method was used to classify the time trend of tuberculosis and then the interrupted time series method was used to identify whether there was a change in incidence after the beginning of diagnosis using the rapid molecular test.
Ricardo Arcêncio

EP19-283-22-Assessment of the quality management system in 23 national reference laboratories for TB in West and Central Africa using the SLIPTA toolAs part of the TB lab project coordinated by the World Health Organization's Supranational Reference Laboratory of Cotonou, the 23 National Reference Laboratories (NRLs) for tuberculosis (TB) in the West and Central Africa region were assessed between July 2019 and January 2020 using the SLIPTA (Stepwise Laboratory Improvement Process Towards Accreditation) tool.
Faridath Massou

EP19-284-22-Results from Namibia’s first TB national disease prevalence survey 2017-2018To better inform the implementation of tuberculosis (TB) control activities in Namibia, it was necessary to quantify the magnitude of the disease burden. The TB disease prevalence survey served as a tool to quantify the burden of TB in Namibia to enable improvement of TB control and, ultimately, end the TB epidemic.
Nunurai Ruswa

EP19-285-22-Bayesian latent class analysis versus composite reference standards for assessing TB pleuritis diagnostic test accuracyWe used latent class analysis to estimate the diagnostic accuracy of Xpert MTB/RIF for tuberculosis (TB) pleurisy, the most common form of extrapulmonary TB. We found that our estimates differed dramatically from accuracies derived from a variety of composite reference standards. 
Emily MacLean

EP19-286-22-A quarterly trend analysis of the contribution of the Wellness on Wheels intervention to TB case finding in Kano State, NigeriaThe aim of the study is to analyse the contribution of the Wellness on Wheels mobile diagnostic unit (WOW MDU) to case notifications in Kano state, Nigeria. The study showed that systematic screening using the WOW MDU is an effective method of increasing tuberculosis case notification rate and this can be scaled-up.
Mustapha Tukur

EP19-287-22-ARREST-TB: Accurate, Rapid, Robust and Economical diagnostic Technologies for TBWe share the significant progress made by ARREST-TB, a multilateral project funded by the EU’s Horizon 2020 programme, the Ministry of Science and High Education of Russian Federation, and India’s Department of Biotechnology, towards the development of frugal diagnostic devices for tuberculosis and drug resistance profiling.
Seshasailam Venkateswaran

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EP15-239-22-Schoolchildren as TB ambassadors played crucial role in fighting TB epidemic by disseminating messages of symptoms and free treatment in five districts in OdishaSchoolchildren as tuberculosis (TB) ambassadors played a crucial role in fighting the TB epidemic by disseminating messages of symptoms and free treatment among their peers, family members and neighbourhood in five National TB Programme districts of Odisha. The low cost intervention/model proved beneficial to the target population in containing TB infection and disease control.
Gayadhar Mallick

EP15-240-22-Under fives TB case finding in hard-to-reach areas - a case for MalawiThis abstract narrates the importance of integration of childhood tuberculosis (TB) in the management of childhood illnesses in hard-to- reach areas in Malawi. Capacity building sessions by village clinic providers and provision of recording and reporting tools for daily use enhances the identification of children who are at risk of TB. 
Paul Chiwenkha

EP15-241-22-Caregivers’ beliefs in anti-TB medicines in the African/Indian SHINE trialWe explored beliefs in medicines among the carers of children on anti-tuberculosis (TB) treatment (ATT) in India, South Africa, Uganda and Zambia. This was a substudy of the SHINE trial. Caregivers reported positive belief in ATT and low negative beliefs about medicine in general.
Jessica Workman

EP15-242-22-Active TB case finding in refugee camps: a right for allThis abstract narrates the positive findings on an intervention that has been implemented by volunteers in refugees camps in Malawi. The intervention focused on capacity building and motivating volunteers in tuberculosis (TB) activities.  Good collaboration and co-ordination between volunteers and health workers has shown to find missed cases in vulnerable communities.
Beatrice Mtotha_Nindi

EP15-243-22-Community volunteers: what motivates them to be part of the TB world?Community-based volunteers play a very crucial role in tuberculosis (TB) activities. In 2017, Malawi National TB Control Progamme trained volunteers in awareness creation, advocacy, sputum collection, and transportation and TB screening. Different enablers were provided to the volunteers. We, therefore, analysed the drop-out rate of these volunteers, reasons for dropping out and their needs.
Henry Kanyerere

EP15-244-22-Role of community health workers in patient-centred care for TBIntensifying community-based tuberculosis (TB) services through community health workers showed better results in increased case notification, maintaining a high treatment success rate and DOTS expansion through a patient-centred approach. It also made it easier to introduce any potential interventions successfully.
Sardar Munim Ibna Mohsin

EP15-245-22-Addressing diagnosis delay in TB patients through engagement of Lady Health Workers in PakistanTuberculosis (TB) is one of the major public health problems in Pakistan. Due to a high incidence of upper respiratory infections with overlapping symptoms, particularly productive cough, delay in diagnosis of TB is quite common. Engagement of Lady Health Workers (LHWs) can lead to early diagnosis of TB in rural communities. 
Aamna Rashid

EP15-246-22-The road mapping of the community contribution in the battle to end TB in SenegalIn Senegal, the participation of community-based organisations in the fight against tuberculosis (TB) has shown that community engagement can be a sustainable solution to end TB, especially in low-setting countries.
Alpha Diallo

EP15-247-22-Engaging dairy co-operatives to support TB patients: a pilot from rural Bihar, IndiaActive community institutions like dairy co-operatives can be a vehicle to involve citizens in tuberculosis (TB) response. Beyond awareness, it can result in support to the patient, their families and to health workers.
Manish Bhardwaj

EP15-248-22-Stakeholder perceptions on the ethics, transparency and fairness of clustered trial randomisationWe conducted cluster randomisation for a tuberculosis (TB) diagnostic trial at a public randomisation ceremony attended by site staff and national TB programme representatives. The two-step randomisation process required active stakeholder participation and engagement. Survey responses suggest that public randomisation ceremonies may help to cultivate stakeholder engagement and increase trust in randomisation.
Talemwa Nalugwa

EP15-249-22-Tribal Action Plan Fund utilisation under NTP: how does Chhattisgarh state, in India, fare to improve programme performance?Tribal Action Plan Fund utilisation under National Tuberculosis Elimination Programme: how does Chhattisgarh state, in India, fare on spending to improve National Tuberculosis Elimination Programme (NTP) performance by its budgeted Tribal Action Fund for its beneficiaries?
Gayadhar Mallick

EP15-250-22-TB in the shadow of COVID-19: India's media coverage of TB during the COVID-19 pandemicThe media plays a crucial role in setting the public health agenda by raising public awareness and building discourses that make or break governments’ policy implementation. A brief evaluation of the media coverage of tuberculosis (TB) in 2020 was conducted to document the discourse around TB before, and during, the COVID-19 pandemic.
Almas Shamim

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EP11-197-22-Implementation of a mHealth strategy to increase linkage to and engagement in HIV care among people with TB and substance use in Irkutsk, SiberiaWe implemented a mobile health intervention designed to improve linkage and engagement in care for a tuberculosis/HIV co-infected, substance-using population in Irkutsk, Siberia. We evaluated the impact of this intervention, called MOCT (Russian for ‘bridge’), on various patient adherence measures as well as clinical outcomes over six months.
Jacqueline Hodges

EP11-198-22-Concomitant hepatitis B or C infection in patients with TB in the Netherlands: results of screening specific risk groupsThe Dutch Thoracic Society recommends screening specific risk groups of tuberculosis (TB) patients for hepatitis B and C. Data on this policy has been registered in the national TB register since 2019. Results show that this policy may contribute to elimination strategies set for these diseases in the Netherlands.
Jossy van den Boogaard

EP11-199-22-Impact of universal TB screening (TB-Surge) on HIV case finding in selected facilities. Lessons from the TB-Surge intervention in Akwa Ibom State, NigeriaUniversal tuberculosis (TB) screening - TB-Surge - was implemented to find missing TB cases in health facilities in AkwaIbom, a Nigerian state with high TB-HIV burden. Based on World Health Organization recommendation, HIV testing was offered to patients with presumptive TB. Universal TB screening can contribute significantly to early HIV diagnosis and commencement of antiretroviral theory (ART). 
Chukwuemeka Austin Ihesie

EP11-200-22-An assessment of free radical oxidation of small intestine enterocyte proteins in HIV-TB co-infectionThe article is devoted to the study of free radical processes in the mucous membrane of patients with HIV-TB co-infection. It is known that these processes are intensified under conditions of hypoxia, including cytotoxic origin caused by the inflammatory response in the lung tissue.
Liliia Todoriko

EP11-201-22-Monocyte and lymphocyte ratio as a predictor of TB among people living with HIV after antiretroviral therapy initiationIt is a challenge to diagnose tuberculosis (TB) among people living with HIV (PLWH) due to many of them having atypical presentation. We have demonstrated a simple tool that can help us predict TB incidence using monocytes to lymphocytes ratio (MLR) among HIV-infected people on antiretroviral therapy (ART).
Sivaporn Gatechompol

EP11-202-22-Comorbidities in Filipino people with active-TB disease: baseline data from the Starting Anti-TB Treatment (St-ATT) cohortFilipino data on the prevalence and patterns of comorbidities of malnutrition, diabetes, hypertension and anaemia are scarce. Malnutrition (BMI <17.0 kg/m2) was a common comorbidity (23.1%) followed by diabetes (22.7%), hypertension (14.8%), then anaemia (13.4%). Having >=1 comorbidities was more common in those with drug-resistant TB than those with drug-sensitive TB (61.8% vs 54.6%, p=0.05).
Shuichi Jack Suzuki

EP11-203-22-Prevalence of disseminated TB in HIV-infected persons admitted with sepsis at a tertiary hospital in western KenyaDiagnosis of disseminated tuberculosis (TB) in Persons Living with Human Immunodeficiency Virus (PLHIV) has been a challenge especially in resource-limited settings. The World Health Organization recommends lateral flow lipoarabinomannan antigen assay (LF-LAM) to aid in the diagnosis of active TB in PLHIV. However, its uptake in Kenya is still wanting.
Caroline Gituku

EP11-204-22-Is TB a major comorbidity in adolescent girls and young women living with HIV? A case in Turkana and Homa Bay Counties, KenyaWe documented tuberculosis (TB) testing, diagnosis, treatment initiation and outcomes of adolescent girls and young women (AGYW). AGYW received a comprehensive intervention including HIV testing, antiretroviral therapy (ART) initiation and treatment monitoring as well as increased access to GeneXpert MTB/RIF testing and alcohol acid fast bacilli, plus treatment of drug-sensitive TB with fixed dose combination.

Phelix Mboya

EP11-205-22-Is it necessary to screen for TB in diabetes patients and how to do it? An endocrinologist-based questionnaire survey in Hunan Province, ChinaIs it necessary to screen for tuberculosis (TB) in diabetes patients and how to do it? Let's see what the endocrinologists think and how they do it from an endocrinologist-based questionnaire survey in Hunan Province of China.
Chengli Bei

EP11-206-22-Prevalence of malarial and HIV co-infection among TB presumptive and asymptomatic children aged <5 years in Western KenyaWhile the intersection between HIV and tuberculosis (TB) is well documented, despite the high burden globally of TB and malaria among children, co-infection data is lacking. We studied the prevalence of malaria and HIV co-infection among Kenyan children aged <5 years with presumptive TB compared to asymptomatic controls.
Mark Fajans

EP11-207-22-Incidence of hypokalemia among drug-resistant TB patients receiving delamanid-containing regimen in LesothoA delamanid-containing regimen is commonly used in Lesotho even though it belongs to group C. This is mainly due to its safety profile as well as absence of drug-drug interaction with certain antiretroviral therapy (ART) and, as such, we investigate the incidence of hypokalemia in drug-resistant tuberculosis patients receiving a delamanid-containing regimen.
Lawrence Oyewusi