19 October-1 December 2020
The 51st Union World Conference On Lung Health
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E-posters
EP25-Lung health across the lifespan
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EP25-Lung health across the lifespan
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EP25-334-23-Effectiveness of the 10-valent pneumococcal conjugate vaccine against radiographic pneumonia in children in rural Bangladesh: a case-control studyWe conducted a matched case-control study between 2015-2017 using clinic and community controls in Sylhet, Bangladesh. Overall, adjusted vaccine effectiveness using clinic controls was 21.4% (95%CI,-0.2%, 38.4%) for >2 PCV10 (pneumococcal conjugate vaccine) doses and among 3-11 month olds was 47.3% (10.5%, 69.0%) for three doses.
Salahuddin Ahmed

EP25-335-23-It’s not TB but what could it be? Abnormalities on chest X-rays from the 2016 Kenya national TB prevalence surveyThe prevalence of diseases other than tuberculosis (TB) detected during chest X-ray (CXR) screening is unknown, yet it is important to provide patient-centred care during screening programmes. This study quantifies and characterises additional non-TB abnormalities that require further clinical input. These abnormalities may go undetected when using computer aided diagnosis.
Brenda Mungai

EP25-336-23-Supplemental oxygen in Queen Elizabeth Central Hospital, Malawi: a prospective cohort study of patients admitted to medical wardsOxygen is a potentially life saving drug that is often in limited supply in sub-Saharan Africa. This prospective cohort study explores the time course of hypoxaemia and response to oxygen therapy in a teaching hospital in Malawi. It aims to better rationalise the distribution of oxygen therapy in resource-limited settings.  
Helen Thomson

EP25-337-23-Searching for microbiome predictors of poor outcomes among infants with respiratory syncytial virus-associated pneumonia in BotswanaThe upper respiratory microbiome is associated with susceptibility to lower respiratory viral infections, but its impact on clinical outcomes in viral pneumonia is unknown. We sought to identify respiratory microbiome related factors associated with poor outcomes among children aged 1-23 months hospitalised with respiratory syncytial virus-associated pneumonia in Botswana.
Sweta M. Patel

EP25-338-23-Integration of obstructive lung disease diagnostics into primary care in limited-resource settings: is there a cost advantage?In resource-scarce settings, systems of patient referrals from primary to secondary care is absent. Specialists handle management and diagnosis of respiratory illnesses which leads to cost inefficiencies. This abstract compares the costs of integrating diagnosis and management systems of obstructive lung diseases within primary care to the standard of care.
Rahma Altaf

EP25-339-23-Predictive value of pulse oximetry for mortality among infants and children in rural Malawi presenting to primary care with World Health Organization-defined pneumoniaThe impact of pulse oximetry on mortality during primary care pneumonia management in African children is unknown. We sought to address this gap by evaluating paediatric pneumonia case fatality when applying World Health Organization guidelines with, and without, oximetry in Malawi.
Eric D McCollum

EP25-340-23-Association between fine particulate matter air pollution and emergency room visits for respiratory illnesses among adults in Karachi, PakistanIn 2018, the average air pollution in Karachi, Pakistan, was poor. In a country with weak healthcare infrastructure, the impact of air pollution on respiratory health and hospitalisation may be severe. This study explores the association between air pollution and risk of emergency room visit, within this setting.
Arman Majidulla

EP25-341-23-Syndromic diagnoses and management of patients presenting to health facilities in four provinces of Viet NamThe study used a syndromic approach to evaluate the prevalence of common respiratory conditions, and the treatment provided, among patients presenting with respiratory symptoms at four levels of health facilities in Viet Nam. 
Erick Wan-Chun Huang

EP25-342-23-Pulmonary function testing and predictive equations in child population in Mbeya, TanzaniaDespite the high burden of respiratory diseases, spirometry reference values for children are available for only a few African countries. We have performed a cross-sectional study with 284 children in Mbeya, Tanzania, to obtain local prediction equations and compare them with GLI equations.
Elimina Siyame

EP25-343-23-Antimicrobial susceptibility patterns of rapidly growing mycobacteria respiratory isolates: a 10-year experience in a mycobacterial research centre in ColombiaTreatment of non-tuberculous rapidly growing (NT-RGM) mycobacteria is challenging as it requires multidrug therapy with low success rates. This study collected data on NT-RGM respiratory isolates during 2010 to 2019. Results showed high resistance levels especially with doxycycline. Moxifloxacin demonstrates poor activity against M. abscessus and clarithromycin susceptibility profile was low.
Laura Victoria

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E-posters
EP20-Community healthcare workers in evidence
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EP20-Community healthcare workers in evidence
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EP20-288-23-Household contact tracing of pulmonary bacteriologically-confirmed TB patients by community health workers in Bumula sub-countyCommunity health workers can effectively implement household contact tracing in resource-limited settings. Contact tracing of bacteriologically-confirmed tuberculosis (TB) patients is a strategy that can be used in finding the missing TB cases and to increase the uptake of isoniazid preventive therapy in children under 5 years of age.
Robert Magomere

EP20-289-23-“After we gave their children polio vaccine we also asked if anyone was coughing"..... exploring programme integration through experiences of front line health workers in NigeriaA phenomenological qualitative research methodology was used to explore health workers' perception of programme integration. We found that simple interventions with minimal documentation can be successfully integrated at the community level. The strengths of the polio vaccination intervention were leveraged to improve tuberculosis control in our setting.
Chukwuebuka Ugwu

EP20-290-23-Can point-of-care CRP improve symptom-based TB screening for detection of TB in the community?New tools for screening tuberculosis (TB) are required in high-burden settings. We evaluated the performance of point-of-care (POC) C-reactive protein (CRP) alone, and in combination with symptom screening, for identifying TB in the community in 701 participants from Zambia and South Africa.
Maria Ruperez

EP20-292-23-The roles of community cadres in applying virtual case finding due to the COVID-19 pandemicIndonesia is still facing challenges in tuberculosis (TB) case finding as the preventive action for TB transmission. Home visits by community cadres for contact investigation is the key strategy.  But this activity had to stop because of the COVID-19 pandemic.  Now, virtual screening is an alternative for case finding.
Esty Febriani

EP20-293-23-Finding missing people with TB: the role of community health workers/volunteers in TB contact tracing in Tanzania (January–March 2020)Finding missing people with tuberculosis (TB) using community health workers/volunteers is of paramount importance in attaining the United Nations High-Level Meeting targets. The overwhelmed health facility staff and TB coordinators need to engage community platforms and link with the confirmed TB patient's contacts for follow-up in the community.
Godwin Munuo

EP20-294-23-Community health workers at the front line: task shifting shows high TB sputum rates at primary healthcare level in King Cetshwayo District, KwaZulu-Natal, South AfricaTrained community health workers take on important activities to improve case finding, diagnosis and support of drug-sensitive tuberculosis (TB) patients in a semi-rural, resource-constrained high TB burden setting of the province of KwaZulu-Natal in South Africa.
Liesbet Ohler

EP20-295-23-The comparative yield of contact investigations from an index patient-led contact tracing approach and a community healthcare provider-led approachThe comparative yield of contact investigations from an index, patient-led contact tracing approach and a community healthcare provider-led approach, showed that index patient-led contact tracing is an effective approach for finding missed tuberculosis (TB) cases quickly and could be employed among youths and communities with high stigma index.
Catherine Kunihira

EP20-296-23-Improving systematic TB case finding for community platforms in low-resource settings in Lao PDRThe Lao PDR National TB Center implemented a comprehensive tuberculosis (TB) case finding model in two districts in Champasack province. The systematic case finding pilot engaged village heath workers to screen symptomatic persons and identify vulnerable population and to refer both groups for 100% GeneXpert testing to improve treatment coverage rates.
Sakhone Suthepmany

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E-posters
EP21-TB as an occupational hazard
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EP21-TB as an occupational hazard
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EP21-297-23-Comparison of latent TB infections among general vs TB healthcare workers in MyanmarSince healthcare workers are at risk of acquiring tuberculosis (TB) infection, it is important to investigate which type of healthcare workers are at higher risk. This article compared the prevalence of latent TB infections among general healthcare workers against TB healthcare workers and explored the associated factors.
Moe Hnin Phyu

EP21-298-23-Assessing TB case notification among coal miners and their contacts in Balochistan, PakistanIn Balochistan, Pakistan, the first active case finding intervention among coal miners and their contacts was conducted between January and December 2019. It aimed to increase tuberculosis (TB) case detection through three approaches - verbal screening camps, screening through outreach and contact tracing. Patients were diagnosed using Xpert and treatment outcomes documented.  
Kinz ul Eman

EP21-299-23-Reaching the feared, but marginalised, artisanal small-scale miners community with TB servicesZimbabwe is a country endowed with minerals in the great dyke. Large to small scale mining, both formal and informal, are practised. Illegal, informal ASM (artisanal small-scale miners) mining is exacerbated by the escalating economic hardships and high unemployment levels. Its illegality drives marginalisation of health services. TIMS programme intervention has reached the marginalised ASM. 
Donald Dennis Tobaiwa

EP21-300-23-Evaluating the impact of TB infection prevention and control measures in key population wards in South AfricaWe analysed data from the National Health Laboratory Service to understand the impact of administrative controls on case finding in key population wards in South Africa. We observed an overall increase in cases identified in key population wards between pre- and post-intervention periods. This intervention should be scaled further.
Alexander Moran

EP21-301-23-Implementation of TB infection control practices: the case of MalawiTuberculosis (TB) infection prevention and control (IPC) is a key strategy in preventing TB among people living with HIV. In 2015, Malawi National TB Programme revised TB-IPC guidelines. About 850 healthcare workers were trained. N95 masks were procured and distributed to health facilities. Mentorship and support supervision were instituted. We analysed the implementation of TB-IPC practices from 2016-2019.
Henry Kanyerere

EP21-302-23-Strengthening airborne infection control measures in Mumbai health facilities, 2016-2020The COVID-19 pandemic highlights the importance of having infection control practices in place at healthcare facilities (HCFs). SHARE INDIA and Centers for Disease Control and Prevention collaborated with Municipal Corporation of Greater Mumbai to build capacity and strengthen airborne infection control measures in primary and secondary HCF in 10 Mumbai wards.
Satish Kaipilyawar

EP21-303-23-Screening of healthcare workers in Zambia: care of the carers 2018-2019Due to undocumented burden of tuberculosis (TB) among healthcare workers (HCWs), symptomatic TB screening was conducted country-wide. The screening was carried out to determine the burden of TB among HCWs, reduce TB related morbidity and mortality and hospitalisation, as well as help retain a healthy workforce.  
Clara Chola Kasapo

EP21-304-23-Comparing two fit test methods of commonly used N95 respirator in South African healthcare settingsRespiratory protection is a vital component in protecting workers’ health. Although respirators are widely used in healthcare settings, the implementation of a successful respiratory programme has been difficult, particularly in resource-constrained settings like South Africa. Therefore, fit testing of respirators is necessary to screen out poor-fit in respiratory protective equipment.



Katekani Ngobeni

EP21-305-23-Screening of latent TB infection in healthcare workers at a hospital in South Africa using interferon gamma release assay: preliminary findingsIn South Africa, healthcare workers (HCWs) are at greater risk of acquiring tuberculosis (TB) disease than the general population. Surveillance for latent TB infection is important to protect both HCWs and patients.  World Health Organization guidelines recommend regular screening of HCWs in low-incidence settings, however, the feasibility and implementation considerations in high-incidence settings is incompletely understood.
Matsie Mphahlele

EP21-306-23-Yield of TB infection among healthcare workers in Afghanistan: a cross-sectional studyThe yield of tuberculosis (TB) infection and disease among healthcare workers (HCWs) was not known in Afghanistan. We assessed the HCWs using TST and chest X-ray. The findings show higher yield of TB infection and disease among HCWs in Afghanistan and TB infection control must be applied to all healthcare settings.
Ghulam Qader

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E-posters
EP24-TB innovative strategies to find the missing cases
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EP24-TB innovative strategies to find the missing cases
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EP24-325-23-Engaging patient medical vendors in TB case finding: the pros and consPatient Medical Vendors (PMVs) are an informal medical outfit that are widely patronised by the majority of the populace in Anambra State Nigeria, this Global fund Caritas Nigeria private sector intervention rant engaged PMVS for TB case finding, this Abstract reviewed the process of engagement, their Case contribution and challenges encountered.
Chidimma Ezeobi -Okoye

EP24-326-23-Enhancing TB diagnosis among unengaged, standalone, formal and informal private health facilities in finding missing people with TB in KenyaPrivate provider engagement (PPE): enhancing TB diagnosis among unengaged, standalone, formal and informal private health facilities to find missing people in Kenya with tuberculosis through capacity building of the providers, strengthening linkages and the provision of sample transport mechanism.
John M. Ng'ang'a

EP24-327-23-The role of community-based interventions to reach out to underserved populations and increase the success rate of TB treatment in Gaza Province, Mozambique, 2019The following abstract assesses the strategy to provide tuberculosis (TB) services to hard-to-reach communities in a low-income setting through active case finding in Gaza. This province aggregates key TB determinants, such as historic mining migration to South Africa and the high burden of HIV. 
Bachir Macuacua

EP24-328-23-TB active case finding in fragile post-conflict areas in Darfur, SudanTuberculosis (TB) services in the Al Malha locality were, throughout the years, affected by the Darfur conflict. TB active case finding was adopted to increase case detection rates, improve the quality of the TB services and increase health awareness. Unfortunately, after finishing the project the TBMU was closed. 
Muaz Hassan

EP24-329-23-Low male yield from community-based TB contact tracing: experiences from community contact tracing in LesothoLesotho is a high tuberculosis (TB) burden country with low treatment coverage. Community TB contact tracing, adopted to improve case finding, appears to be missing men. We analysed programme performance across the contact tracing cascade to look for differences by age and sex.
Tafadzwa Chakare

EP24-330-23-TB screening at Bungoma Bus Park, Bungoma County, KenyaRegular tuberculosis (TB) screening in bus parks can led to an increase in TB case notification, eventually reducing transmission of TB. Adherence counselling and the provision of TB drugs, during convenient hours, to touts and drivers can reduce TB treatment interruption in this group.
Robert Magomere

EP24-331-23-Yield and coverage of active case finding interventions for TB control in high burden countries: a systematic review and meta-analysisThis systematic review and meta-analysis summarises data on outcomes of active case finding activities. We highlight how, yield of active tuberculosis (TB) cases and screening coverage, differs in various populations and settings, as well as how different screening and diagnostic methods affect the yield of TB cases.
RUTH DEYA

EP24-332-23-An adaptive decision-making approach to efficiently deploy TB case finding in high burden communitiesStrategies are needed to optimise the use of community-based active case finding (ACF) in high tuberculosis (TB) burden communities. We propose an adaptive decision-making approach, which uses a Bayesian sampling algorithm, to guide ACF resource allocation in order to improve case-finding yield in communities with a prevalence of undiagnosed TB.
Abigail de Villiers

EP24-333-23-Patent and propriety medicine vendor-led community engagement: an innovative approach to finding missing TB cases in rural communities in Boki local government, NigeriaThe missing tuberculosis (TB) cases are in the community. Effectively engaging communities in finding missing persons with TB has been both challenging and cost intensive. The patent medicine vendor resides with the people in the community and could have a critical role in engaging communities in finding missing TB cases.
Igbaji Basil Uguge

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E-posters
EP28-Making the most of short money to fight TB
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EP28-Making the most of short money to fight TB
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EP28-364-23-Examining the cost of delivering TB prevention, diagnosis and treatment in the Philippines, 2018The Philippines tuberculosis (TB) programme conducted a national study to establish the cost of TB service delivery following recent standards. Unit costs for 21 TB interventions and 39 technologies in 2018, better equip planners to understand cost variations across facility type, urbanicity and ownership, to inform the provision of people-centred, affordable services.
Inés Garcia Baena

EP28-365-23-Examining the cost of delivering TB prevention, diagnosis and treatment in India, 2018Unit cost data is important for planning and priority setting for a programme. However, there is paucity of such data for tuberculosis (TB) in India. This study estimated unit costs of key services related to TB, from a provider perspective, using data from 20 health facilities in two states in India.  
Susmita Chatterjee

EP28-366-23-First national TB patient cost survey in Lao PDR: assessment of the financial burden faced by TB-affected households and comparisons by drug-susceptibility and HIV statusLao PDR National TB Programme conducted the first national tuberculosis (TB) patient cost survey in 2018-2019 to assess the magnitude of the financial burden, due to TB, and the percentage of TB-affected households facing catastrophic costs. The survey focused on sampling drug-resistant TB and TB-HIV patients, in addition to nationally representative samples.
Takuya Yamanaka

EP28-367-23-Economic evaluation of patient costs associated with TB diagnosis and care in Papua New GuineaEconomic burden incurred by tuberculosis (TB) patients and their households due to TB disease can affect patients’ adherence and outcomes and increase the risk of TB transmission. A national survey has been conducted in Papua New Guinea to evaluate the magnitude and main drivers of these costs.
Margaret Kal

EP28-368-23-Catastrophic costs for TB patients before treatment starts: results from a multicountry, observational cohort study in sub-Saharan AfricaIn attempting to contextualise and quantify the cost burden of tuberculosis (TB) to individuals and households, the World Health Organization, through the End TB Strategy, introduced a TB-specific indicator of economic risk called ‘catastrophic costs’. We use different approaches to determine the proportion of TB patients facing catastrophic costs during pre-treatment TB care.
Kamban Hirasen

EP28-369-23-Financial risk protection benefits of expanded TB control interventions in Ethiopia: an extended, cost-effectiveness analysis modelling studyWe used models to estimate reductions in tuberculosis (TB) related catastrophic costs with aggressive expansion of TB services in Ethiopia from 2017 to 2035. Improvement in the delivery of TB services may substantially reduce the catastrophic cost burden on affected households.
Lelisa Fekadu Assebe

EP28-370-23-Cost-effectiveness of nutritional supplementation to decrease TB incidence and mortality in IndiaAt least one in three tuberculosis (TB) cases in India are attributable to undernutrition. Addressing undernutrition is, therefore, crucial to achieve the Indian government’s aim of eliminating TB. We describe a modelling approach to assess cost-effectiveness of nutritional supplementation to prevent TB cases and deaths.
Pranay Sinha

EP28-371-23-Modelling the impact of a bedaquiline-containing short-course regimen on cost and disease burden of drug-resistant TB in the PhilippinesThis study explores the comparative benefits of the optimal implementation of the World Health Organization's recommended drug-resistant tuberculosis (TB) treatment using a bedaquiline-containing, short-course regimen in the Philippines. It explored the benefits, set alongside using established injectable-containing regimens, on reduction in disease burden, healthcare cost burden and aversion of disability-adjusted life years over 2020-2040.
Mpobela Abela Agnarson

EP28-372-23-The potential value of biomarker-led preventive therapy in eliminating TB: a modelling analysisNovel biomarker signatures offer prognostic value in identifying individuals at imminent risk of developing active tuberculosis (‘incipient’ TB). Using a mathematical model of TB transmission in Chennai, India, we examine whether such tools offer cost-effective approaches for TB control in a high burden setting.
Saskia Ricks

EP28-373-23-Do evaluations of Tuberculosis Active Case Finding report estimates of resource need? A review of the evidenceActive case finding (ACF) interventions aim to improve early TB case detection and prevent transmission of infection- but what resources are needed to run an ACF intervention, and are these routinely reported in evaluations? We review 65 ACF interventions for their reporting on resource needs.
Madeleine Clarkson

EP28-374-23-Estimating the value-based price of new TB vaccines in India and ChinaWe estimate the value-based price of new tuberculosis (TB) vaccines in China and India using a dynamic transmission mathematical model of TB and rifampicin-resistant and multidrug-resistant tuberculosis (RR/MDR-TB), attached to a country specific cost model. We incorporate epidemiologic uncertainty and uncertainty in cost of delivery of TB and vaccine services into our estimates.
Chathika Weerasuriya

EP28-375-23-Optimising investments in Mozambique’s TB response: results of a TB Optima modelling studyTo achieve the goal of ending tuberculosis (TB), it is crucial to determine which models of TB care and treatment should be prioritised, especially in the context of limited resources. The team used Optima TB, a mathematical model of TB transmission and disease progression, integrated with an economic and programme analysis framework.
Pereira Zindoga

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E-posters
EP23-TB in children and adolescents
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EP23-TB in children and adolescents
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EP23-319-23-Chest-X-ray for TB diagnosis in children under 5 years living with a person with bacteriologically confirmed pulmonary TB in Africa: quality, inter-reader agreement and performancesThis study evaluates quality, inter-reader agreement and performances of chest X-rays (CXR) for tuberculosis (TB) diagnosis in children under 5 years of age, who are living with a person with bacteriologically-confirmed pulmonary TB, as part of a contact investigation study using systematic CXR.
Kobto Ghislain Koura

EP23-320-23-Classification and regression trees to predict TB disease in childrenThe diagnosis of tuberculosis (TB) disease in children is complicated by non-specific symptoms and low sensitivity of conventional diagnostic tests. We use classification and regression tree analysis to identify the best predictors for accurately classifying children (0-4, 5-9 and 10-14- years-old), who are exposed at home to TB, with TB disease.
Meredith Brooks

EP23-321-23-Epidemiology and clinical manifestations of adolescent TB in UkraineWe analysed data from 2491 cases of adolescent tuberculosis (TB) in Ukraine. We identified risk factors for each of four clinical presentations: cavitary, pleural, extrathoracic and rifampicin-resistant TB. This work can help guide diagnosis and clinical decision making in a traditionally overlooked age group for TB.
Silvia Chiang

EP23-322-23-Prevalence and predictive factors of active TB in children under 5 years of age living with a person with bacteriologically-confirmed pulmonary TB in AfricaOur study was conducted in four African countries to identify factors predictive of active tuberculosis (TB) in children under 5 years of age living in contact with a bacteriologically-confirmed pulmonary TB case. The factors identified can be used to create a score to screen for childhood TB during home visits.
Kobto Ghislain Koura

EP23-323-23-Childhood TB trends in Zambia over five years (2014-2019)Childhood tuberculosis (TB) has been underserved until recent years when there has been renewed national commitment. The Zambian Ministry of Health, through the National Tuberculosis Programme, has embarked on high impact, data driven interventions aimed at turning the tide that once seemed grim as shown by this trend analysis.
Chalilwe Chungu

EP23-324-23-Routine South African TB data: are we doing enough for children and adolescents?Although children and adolescents with tuberculosis (TB) are globally recognised as important key populations, limited approaches exist to evaluate how well TB programmes address these groups.  We used routine data to analyse TB case notification indicators disaggregated by age (0-4, 5-9, 10-14 and 15-19 years) and discuss South Africa’s progress.
Karen Du Preez

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E-posters
EP27-Difficult problems in TB infection and treatment
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EP27-Difficult problems in TB infection and treatment
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EP27-354-23-Difference in persistent TB bacteria between in vitro and sputum from patients: implications for translational predictionsThis abstract covers work that revealed difference in phenotypic resistance between in vitro and in human tuberculosis patients, prior to initiation of chemotherapy. The findings will have impact on the prediction of EBA activity from in vitro, drug-effect experiments.
Alan Faraj

EP27-355-23-Characterisation of the metabolic urine profile using nuclear magnetic resonance spectroscopy to monitor treatment of TBEarly tuberculosis (TB) diagnosis in children is crucial for prescribing prompt treatment and reducing mortality. We identified a correlation between the nuclear magnetic resonance-based urinary metabolic profile and the standardised case definitions for TB diagnosis in children, which may improve childhood TB detection by shortening the time of diagnosis and initiation of treatment.
Patricia Comella-del-Barrio

EP27-357-23-Systemic inflammation in pregnant women with and without latent TB infectionStudies have reported increased systemic inflammation in adults with latent tuberculosis infection (LTBI+) compared to those without LTBI. However, as potential differences have not been assessed in pregnant populations, we compared levels of systemic inflammation by LTBI status in pregnant women with, and without, LTBI in Pune, India. 
Rupak Shivakoti

EP27-359-23-Predicting the efficiency of the treatment of drug-resistant TB depending on the polymorphism variation of glutathione-S-transferase genesGenes, the expression of which plays a key role in the resistance of cells to the effects of free radicals by lipid peroxidation and oxidative modification of proteins, preventing breakage of DNA, biosynthesis of prostaglandins, transportation and metabolism of bilirubin, hormones are genes which code the synthesis of glutathione-S -transferase.
Ihor Semianiv

EP27-360-23-Usefulness of gene sequencing for identification of non-tuberculous mycobacteriaCorrect identification is crucial to manage non-tuberculous mycobacteria (NTM) infection. Line probe assays are widely used for identification of NTM, but they cover 20-30 species. Our study showed that 16S rRNA and rpoB gene sequencing were able to give a species name for most isolates not identified by line probe assay.
Chang-Ki Kim

EP27-362-23-Latency-associated antigen Rv1733c of Mycobacterium tuberculosis improves the value of differential diagnosis of active TB and latent TB infectionCurrently available interferon-γ release assay cannot reliably differentiate active tuberculosis (ATB) from latent tuberculosis infection (LTBI). Our research shows that Rv1733c SLP can be used as an alternative antigen for T cell-based TB diagnostic tests, in combination with ESAT-6 and CFP-10, to conducive differentiate between ATB and LTBI.
Huimin Ma

EP27-363-23-Dried blood spot sampling to assess rifampicin pharmacokinetics among TB patients in Paraguay: native indigenous and general populationA minimally invasive, alternative sampling matrix collected utilising limited sampling time points has gained significant traction with a potential to make therapeutic drug monitoring an attainable goal in settings with tuberculosis (TB) endemicity. We evaluated rifampicin pharmacokinetic parameters, among native indigenous and general Paraguayan TB patients, using dried blood spots sampling. 
Samiksha Ghimire

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EP22-TB adherence to treatment
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EP22-TB adherence to treatment
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EP22-307-23-Implementation of TB preventive treatment in South Africa: the urgent need to address gapsTuberculosis (TB) and HIV are major global public health concerns. Providing TB preventive treatment (TPT) to people at risk of progressing to TB disease decreases TB transmission and TB-related mortality. We compared TPT initiations and completions between two fiscal years to identify programme gaps.
Katlego Motlhaoleng

EP22-308-23-TB preventive treatment preferences among children in Eswatini: a mixed methods studyUnderstanding preferences regarding tuberculosis preventive treatment (TPT) regimens’ characteristics and service delivery models, is key to efforts to improve TPT initiation and completion. We report on results from a mixed methods study, including a discrete choice experiment and qualitative interviews among children in Eswatini, an African country with high TB burden.
Yael Hirsch-Moverman

EP22-309-23-Low completion rate of once-weekly rifapentine plus isoniazid regimen among elderly populationWith the advanced preventive therapy as a cornerstone of End TB, a better regimen which is easier for elderly contacts to complete is crucial, since interruption of preventive therapy among elderly populations is not improved by providing 3HP.
Pei-Chun Chan

EP22-311-23-Risk based patient-centred strategies for TB treatment. Inference from a prospective cohort studyTo optimise strategies for prevention and management of tuberculosis, (TB) we need to adapt available resources and implement patient-centred approaches. Implementing different treatment strategies considering a patient baseline risk, organisation of healthcare delivery and interventions for social inclusion, will probably result in better TB outcomes in resource-constrained systems.
Fernando Rubinstein

EP22-312-23-Perspectives of multidrug-resistant TB patients on the use of treatment supporters: experience from Lagos, NigeriaA qualitative study to explore the patient perspective when using treatment supporters in multidrug-resistant tuberculosis (MDR-TB) care. From the patients’ perspectives, they found it very supportive and family members were preferred as treatment supporters because of the closeness, and the ability to support, patients emotionally in the course of treatment.
Oluremilekun Kusimo

EP22-313-23-Improving treatment adherence with technology and patient-centred care in MoroccoA comprehensive tuberculosis (TB) management programme using mHealth and patient-centred management was implemented to reduce the rate of patients lost to follow-up in Morocco. Patients who enrolled in the programme showed an improved treatment success rate and the new TB management programme could be applicable in other countries under similar circumstances.
Narae Moon

EP22-314-23-The effect of digital dosing monitoring on the adherence of patients treated for TB in Viet NamNon-adherence is an important risk factor for relapse among patients with tuberculosis (TB). This study evaluated the effect of digital adherence support, using a Medication Event Reminder Monitor (MERM), for outpatients treated for newly diagnosed, smear-positive pulmonary TB in Viet Nam.
Thu-Anh Nguyen

EP22-315-23-Impact of health-related quality of life on treatment adherence during treatment for pulmonary TBThis abstract describes how health-related quality of life, while receiving drug-sensitive tuberculosis (TB) treatment, impacts on treatment adherence. It is part of an ongoing observational cohort study among adult patients receiving treatment for TB through national TB programmes in The Gambia, Mozambique, South Africa and Tanzania. 
Tembeka Sineke

EP22-316-23-Evaluation of the integrated multidrug-resistant and rifampin-resistant TB patient management approach in Wuhan Jinyintan Hospital, Hubei Province, ChinaA retrospective analysis of year-one patient data of three intervention cohorts to evaluate the integrated multidrug-resistant tuberculosis and rifampin-resistant tuberculosis patient management approach implemented in Wuhan Jinyintan Hospital, Hubei Province, China
Qi Nie

EP22-317-23-Peer empowerment to strengthen treatment adherence among multidrug-resistant TB patients: field experience in Shaanxi Province, ChinaPeer empowerment was introduced by Xi'an Chest Hospital's medical staff to provide support to local multidrug-resistant tuberculosis patients in order to enhance treatment adherence. This is the field experience in Xi'an, Shaanxi Province in Western China.
Hui Luo

EP22-318-23-Diverse patterns of TB medication adherence seen via directly observed therapy in an observational cohortWe analysed directly observed therapy (DOT) data from a prospective drug-susceptible tuberculosis (TB) cohort in Worcester, South Africa. Participants were more likely to miss doses during the therapy continuation than the initiation phase. Among those who were 60-90% adherent, there was significant variation in the TB treatment adherence patterns.
Tara C Bouton

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E-posters
EPTBS-TBScience 2020 - E-posters - Displayed All Conference Days
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EPTBS-TBScience 2020 - E-posters - Displayed All Conference Days
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All TBScience 2020 E-posters will be displayed from 10 am Central European Summer Time (CEST), on Wednesday, 21 October for the duration of the conference and beyond

EP-TBS-01-Increased neutrophil count and decreased neutrophil CD15 expression correlate with TB disease severity and treatment response
Lerato Ndlovu

EP-TBS-02-Genome-wide identification of Mycobacterium tuberculosis genetic markers associated with the history of BCG vaccination
Kamela Charmaine S. Ng

EP-TBS-03-Characterization of regulatory B-cells for tuberculosis management
Irene Latorre

EP-TBS-04-Different antimycobacterial activity of alveolar macrophages in various lung legions of tuberculosis patients
Sergey Skornyakov

EP-TBS-05-Plasma mediators of phagocytosis in tuberculosis patients during anti-TB treatment and zinc supplementation
Victory Edem

EP-TBS-06-Discerning divergent tuberculosis endotypes: A meta-analysis of individual patient data
Andrew DiNardo

EP-TBS-07-Plasma Interferon (IFN)-g Inducible Protein 10 (IP-10) levels but not the QuantiFERON Gold plus assay correlate with disease severity and paradoxical reactions in extrapulmonary tuberculosis
Isabelle Suarez

EP-TBS-08-Host immune factors related to non-multidrug resistant tuberculosis with treatment history in Vietnam
Naoto Keicho

EP-TBS-09-Risk factors for the development of tuberculosis in children with chronic non-specific lung diseases.
Sofya Nakonechnaya

EP-TBS-10-Polyfunctional T-cells and IL-2 production decrease during pregnancy in women with latent TB infection
Jyoti Mathad

EP-TBS-11-Neutrophils Contribute to Tuberculosis-linked Inflammation and lung pathology
Caleb Nwongbouwoh Muefong

EP-TBS-12-Association of neutrophil-derived inflammatory mediator levels with lung pathology in active tuberculosis at diagnosis
Caleb Nwongbouwoh Muefong

EP-TBS-13-Characterising the BCG-induced antibody response for antigen discovery
Rachel Tanner

EP-TBS-14-ESAT-6 / CFP-10-stimulated metabolic activity of pleural fluid cells if cured tuberculosis or TB / HIV
Sergey Skornyakov

EP-TBS-15-Blood-Based Biomarkers of Tuberculosis in Children Integrating Metabolomic and Transcriptomic Data
Jeffrey A Tornheim

EP-TBS-16-Identification of TGF-β1 in pleural tuberculosis: the possible role in fibrosis
Silvio Renan Pinheiro Victor de Araújo

EP-TBS-17-Analysis of serum microRNAs as pulmonary tuberculosis biomarkers
JaeIn Jung

EP-TBS-18-Up-regulated programmed death protein 1 expression on CD4 T cells in patients with MDR-TB  associated with lung lesion and mycobacterial load
Qi Tan

EP-TBS-19-Malnutrition affects levels of vascular endothelial growth factor levels among children and adolescents with pulmonary tuberculosis?
Caio Pluvier Duarte Costa

EP-TBS-20-Towards identification of protein markers of Mycobacterium tuberculosis H37Rv extracellular vesicles (EV)
MEHALENE JAYARAM

EP-TBS-21-Increased frequency of CD39+ regulatory T cells in the pleural fluid of patients with Tuberculosisin comparison to other exudative causes
Ana Paula Santos

EP-TBS-22-Longitudinal analysis of M. tuberculosis-specific T cell responses demonstrates dynamic T cell responses to ESAT-6 and CFP-10 during pregnancy independently of mitogen responses.
Aparajita Saha

EP-TBS-23-Serum Cytokine Profile as Biomarker for Multi-drug Resistant Tuberculosis
Alahaman Nana Boakye

EP-TBS-24-Reanalysis and validation of Tuberculosis genes signature in blood and pleural fluid from patients with exudative pleural effusion
Raquel da Silva Corrêa

EP-TBS-25-TimBre, Cough based screening of Pulmonary Tuberculosis using Machine Learning that is Explainable and Interpretable
Rahul Pathri

EP-TBS-26-HbA1C as prognostic factor in PTB
Sarang Patil

EP-TBS-27-Better intradermal delivery for bacille Calmette-Guérin (BCG) vaccine by microneedles in healthy adults of S. Korea
Hyejon Lee

EP-TBS-28-MULTIPLEX BIOMARKER ASSAY FOR DETECTION OF MYCOBACTERIUM TUBERCULOSIS
Puneet Gupta

EP-TBS-29-Role of the chemokine receptor CXCR3 in the recruitment and retention of lung resident memory T cells following a pulmonary TB vaccine. 
Warwick Britton

EP-TBS-31-Benefit of Quantiferon-TB Gold plus in incidence of TB disease in Heath care workers of Central Chest Institute of Thailand
piamlarp sangsayunh

EP-TBS-32-The blood monocyte/lymphocyte, neutrophil/lymphocyte and platelet/lymphocyte ratios in children with pulmonary tuberculosis
Larissa Gorbach

EP-TBS-33-Pulmonary tuberculosis patients have an anaerobe-enriched microbiota associated with a pro-inflammatory peripheral host immune phenotype
Charissa Naidoo

EP-TBS-34-The epidemiologic impact and cost-effectiveness of new tuberculosis vaccines on rifampicin resistant and multidrug resistant tuberculosis in India and China
Chathika Weerasuriya

EP-TBS-36-Novel, culture-free, same-day TB diagnosis with ultrasensitive ELISA
Rikiya Takeuchi

EP-TBS-37-Tuberculosis screening in point-of-care settings: Proof-of-concept for a fast and easy sample-to-answer qPCR-based protocol
Alexandre Dias Tavares Costa

EP-TBS-38-Diagnostic accuracy of three urine lipoarabinomannan tuberculosis assays in HIV-negative outpatients
Tobias Broger

EP-TBS-39-To Study The Presence Of Live Mycobacterium Tuberculosis In Resected Lung Specimens Of Patients Undergoing Lung resection Surgery For Post-Tuberculosis Sequelae
Pallavi Purwar

EP-TBS-40-What can tuberculosis prevalence surveys tell us about the duration of asymptomatic bacteriologically-positive disease?
Chu-Chang Ku

EP-TBS-41-An RNA signature for tuberculosis risk in pregnant women: a prospective cohort study from India
Jyoti Mathad

EP-TBS-42-Analysis of mycobacterial trans-renal DNA for the diagnosis of Tuberculous Meningitis in adults.
Manisha Dass

EP-TBS-43-Developing a tool to identify and screen Latent Tuberculosis Infection (LTBI) with likelihood of progression to active Tuberculosis (ATB)
Prashant Singh

EP-TBS-44-QuantiFERON TB plus-negative results in clinically diagnosed paediatric tuberculosis: immune suppression or misdiagnosis?
Gloria Ivy Mensah

EP-TBS-45-Evaluation of a blood-based antigen test for tuberculosis in HIV-exposed children younger than 5 years
Tony Hu

EP-TBS-46-Adverse drug reactions in MDR TB Patients on ATT
Sarang Patil

EP-TBS-47-Species and Drug Susceptibility profile of Non-tuberculous Mycobacteria isolated from presumptive TB cases
PRIYA RAJENDRAN

EP-TBS-48-MAMA-PCR assay for the detection of point mutations associated with drug resistance in Mycobacterium tuberculosis clinical isolates
Raquel Muñiz-Salazar

EP-TBS-49-Genomic diversity in Mycobacterium tuberculosis from human lung resections reveals a high degree of multiclonal infections in a high-burden MDR-TB setting
Miguel Moreno-Molina

EP-TBS-50-Pathogen genome sequencing to guide treatment regimen designs for multidrug-resistant tuberculosis
Hans-Peter Grobbel

EP-TBS-51-An evolutionary functional genomics approach identifies novel candidate regions involved in isoniazid resistance in Mycobacterium tuberculosis
Victoria Furió

EP-TBS-52-Antibiotic Resistance Profile Determination Using Whole Genome Sequencing
Ryan Howard

EP-TBS-53-Rapid genomic drug resistance prediction from clinical Mycobacterium tuberculosis specimens using amplicon based deep sequencing based on Deeplex-MycTB
Stefan Niemann

EP-TBS-54-Multi-resistant tuberculosis and HIV infection in Kinshasa: 2011-2018. DRC “Epidemiological, clinical and therapeutic aspects”
Nicole ANSHAMBI

EP-TBS-55-Long Read DNA Sequencing of XDR/MDR Tuberculosis Samples to Investigate Factors Leading to Resistance and Virulence
Michael Harris

EP-TBS-56-Genome-wide detection of epistasis in antibiotic resistant M. tuberculosis
Anna Green

EP-TBS-57-Population structure, biogeography and transmissibility of Mycobacterium tuberculosis
Luca Freschi

EP-TBS-58-Safety and Efficacy of an MDR-TB All-oral Short-course Regimen in China: An Preliminary Analysis of the MDR-Chi clinical trial
Liang Fu

EP-TBS-59-Drug exposure and minimum inhibitory concentration predict pulmonary tuberculosis treatment response
Xubin Zheng

EP-TBS-60-A novel therapeutic vaccine against multi-drug resistant tuberculosis by T cell-immunity in phase 1 clinical trial.
Masaji Okada

EP-TBS-61-Improving the safety of TB therapy with novel diagnostic biomarkers of liver toxicity – a study in UK and Ugandan patients
Derek Sloan

EP-TBS-62-Tuberculosis meningitis mouse model
Tuhina Gupta

EP-TBS-63-Pharmacokinetics of the three-drug fixed-dose dispersible tablet in children
Aziza Pakhlavonova

EP-TBS-64-Does BCG Vaccination protect against infection with Mycobacterium tuberculosis in Vietnamese schoolchildren?
Puck Pelzer

EP-TBS-65-Time to positivity as a surrogate biomarker of time to culture conversion
Belén P. Solans

EP-TBS-66-Use of the contact management register to identify those with Active and Latent TB, Kenya, Jan-March 2020
RHODA POLA

EP-TBS-67-Predicting Efficacy Outcome of Nine Tuberculosis Drugs in Phase 2a First-in-patients Studies
Nan Zhang

EP-TBS-69-Predicting optimal treatment durations for tuberculosis patients: a risk stratification algorithm and clinical simulation tool
Marjorie Imperial

EP-TBS-70-Adverse Drug Reactions in MDR TB Patients on Category IV Regimen in Western Odisha
SUMAN KUMAR JAGATY

EP-TBS-71-The effect of antiretroviral therapy and preventive tuberculosis therapy with anti-TB drugs on the duration of TB remission in HIV-infected patients
Igor Medvinskiy

EP-TBS-72-A Urine Colorimetric Assay for Levofloxacin Concentrations and Optimized Regimen Development
Prakruti Rao

EP-TBS-73-Development and Application of an Integrated Biomarker - Clinical Endpoint Tool for Late Stage TB Regimen Development and Clinical Trial Design
Marjorie Imperial

EP-TBS-74-Leveraging Neural Networks and Imaging Experts in Loops for Automated Tuberculosis Screening Using Chest Radiographs in Population Screening Programs to ensure efficient workflows.
Amit Kharat

EP-TBS-75-A model for the integration of traditional medicine into conventional medicine for the treatment of Tuberculosis (TB) in Zimbabwe
Winnet Enerita Chipato

EP-TBS-76-Point-of-Care Saliva Assay for Levofloxacin Concentrations and Personalized Dosing in Patients with Multidrug-Resistant Tuberculosis in Tanzania
Sagal Mohamed

EP-TBS-77-PBPK Model Informed Prediction to Evaluate the Effect of Renal Impairment and OCT genotypes on the Ethambutol Disposition
Yumi Park

EP-TBS-78-Development of Population Pharmacokinetic Model of the First-line anti-TB drugs in Korean patients with TB for Therapeutic Drug Monitoring Guided Dose Adjustment
Yumi Park

EP-TBS-79-Model Informed Personalized Dosing Algorithm Development for TB Therapy in Center for Personalized Precision Medicine (cPMTb)
Yumi Park

EP-TBS-80-Classifying adherence trajectories: an innovative tool for regimen development
Stephanie Law

EP-TBS-81-Predicting pretomanid penetration into patient lesions of tuberculosis
Jacqueline Ernest

EP-TBS-82-Rifapentine pharmacokinetics and pharmacodynamics: murine and human models to identify optimal dosing for treatment of latent M. tuberculosis infection
Jacqueline Ernest

EP-TBS-83-SLCO1B1 and SLC10A1 polymorphism and plasma rifampin concentrations in patients with co-morbidity tuberculosis-diabetes mellitus in Baja California, Mexico
Ricardo Perea-Jacobo

EP-TBS-84-Individual-Level Data Meta-Analysis of Adverse Events from Clinical Trials of Drug Sensitive Tuberculosis Treatment Regimens
Leah Jarlsberg

EP-TBS-85-G-clamp-inspired ligands and their effects on G-quadruplexes from Mycobacterium tuberculosis
Egor Shitikov

EP-TBS-86-Prediction of early bacterial activity (EBA) of bedaquiline in tuberculosis
Federico Romano

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E-posters
EP26-Improving knowledge: the benefits for person-centred TB care
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EP26-Improving knowledge: the benefits for person-centred TB care
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All E-posters are accessible via the "E-posters" section of the conference platform until 30 November.

EP26-344-23-Feasibility of appreciative inquiry to co-create an evaluation framework for TB and HIV Extension for Community Healthcare Outcomes (ECHO) implementation in India and TanzaniaEvaluating training and education initiatives such as Project ECHO (Extension for Community Healthcare Outcomes) is essential to understand impact. We describe the feasibility of an appreciative inquiry approach that engages stakeholders in creating an evaluation framework to assess TB and HIV ECHO implementation in India and Tanzania.
Smita Ghosh

EP26-345-23-Creating TB awareness through active involvement of learners in secondary schools: A case of Amref Health AfricaDocumentation of strategies used to create tuberculosis (TB) awareness in public secondary schools in five high burdened counties in Kenya. The school fraternity was equipped with TB education and students were able to create unique TB-related performing arts that were presented during World TB day, reaching various community members.
Christine Mwamsidu

EP26-346-23-Integration of family-focused education and counselling in Daru TB preventive therapy programmeIntegration of family-focused education and counselling into the preventive therapy programme in Daru has led to improved understanding of latent tuberculosis by families of children on treatment. It has also contributed to improvements in treatment adherence and rates of treatment completion.  
Allan Kuma

EP26-347-23-Experience describing co-creation of an assessment framework for implementation of a virtual learning platform: TB Extension for Community Healthcare Outcomes implementation in IndiaProject ECHO (Extension for Community Healthcare Outcomes) leverages virtual video conferencing technology to build capacity, disseminate knowledge and promote mentorship through case-based learning. An appreciative inquiry approach was utilised to engage stakeholders and co-create a comprehensive assessment framework and data collection tools in order to assess TB ECHO implementation in India.
Smita Ghosh

EP26-348-23-Engaging first line care providers for screening and referral of presumptive TB patients in Nigeria: results of a targeted approachCommunity pharmacists and patient medicine vendors play a key role in expanding patient-centred approaches to tuberculosis (TB) care. Stakeholders for TB control need to imbibe the right strategy to engage these important first line care providers for effective and standardised implementation in order to significantly contribute to TB case finding.
Chidubem Ogbudebe

EP26-349-23-Unprepared and unprotected: graduating medical students’ knowledge, attitudes and practices regarding drug-resistant TB in Cape Town, South AfricaSouth Africa has a high burden of drug-resistant TB, which is managed extensively by junior clinicians at the primary care level. In this cross-sectional study, we assessed the knowledge, attitudes and practices of graduating medical students at the University of Cape Town, South Africa.
Johnathan Watts

EP26-350-23-Can patient navigators help potential TB patients navigate the diagnostic and treatment pathway?People brave a variety of social, structural and health system barriers to seek healthcare in fragmented and complex health systems. Patients navigators can change this. We evaluate navigators’ utility in enabling person-centred care in both public and private sector tuberculosis programmes in India.
Miranda Brouwer

EP26-351-23-A new 'normal' for health service provider capacity building in response to the COVID-19 pandemic in the PhilippinesWith travel restrictions and physical distancing to contain COVID-19, a new way of capacity building for healthcare providers is needed. We share the results of synchronous, web-enabled, class-based training on national tuberculosis guidelines, which was conducted for a pool of trainers in place of face-to-face training in the Philippines.
Ruth Orillaza-Chi

EP26-352-23-Study of participant satisfaction with directly observed therapy and TB programme staff members' interpersonal skills, patient education and patient-centred communicationsWe conducted a randomised crossover trial comparing in-person, directly observed therapy (ipDOT) with electronic DOT (eDOT) for tuberculosis (TB) treatment in NYC. We report participants’ satisfaction with both DOT methods as well as responses to questions focusing on TB programme staff members' interpersonal skills, provision of patient education and patient-centred communications.
Marco M. Salerno

EP26-353-23-Knowledge, attitudes and current practices and roles of pharmacy professionals concerning TB treatment in IndonesiaWith 52% of initial care-seeking by tuberculosis (TB) patients happening in pharmacies and drug stores in Indonesia, pharmacies can be an effective channel to direct presumptive TB patients to health facilities for diagnosis and care. This is a digital, cross-sectional survey investigating pharmacy professionals’ knowledge, attitudes and practices concerning TB.
Vania Gones

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